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Aspirin is a weak acid (figure below) that is taken up into the bloodstream by diffusion through cells lining the stomach and the small intestine. One of the two forms of aspirin shown below can cross the plasma membrane of a cell. The pH of the stomach is about 1.5 and that of the lumen of the small intestine is about 6.0. pk = 35 uncharged form charged form The form can cross the lipid bilayer more effectively and thus, majority of the aspirin will be absorbed into the bloodstream through the

Aspirin is a weak acid (figure below) that is taken up into the bloodstream by diffusion through cells lining the stomach and the small intestine. One of the two forms of aspirin shown below can cross the plasma membrane of a cell. The pH of the stomach is about 1.5 and that of the lumen of the small intestine is about 6.0. pk = 35 uncharged form charged form The form can cross the lipid bilayer more effectively and thus, majority of the aspirin will be absorbed into the bloodstream through the

Biochemistry
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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Aspirin is a weak acid (figure below) that is taken up into the bloodstream by diffusion through cells lining the stomach and the small intestine. One of the two forms of aspirin shown below can cross the plasma membrane of a cell. The pH of the stomach is about 1.5 and that of the lumen of the small intestine is about 6.0. pK= 3.5 H uncharged form charged form The form can cross the lipid bilayer more effectively and thus, majority of the aspirin will be absorbed into the bloodstream through the uncharged; small intestine O charged; small intestine O uncharged; stomach lining charged; stomach lining
Transcribed Image Text:Aspirin is a weak acid (figure below) that is taken up into the bloodstream by diffusion through cells lining the stomach and the small intestine. One of the two forms of aspirin shown below can cross the plasma membrane of a cell. The pH of the stomach is about 1.5 and that of the lumen of the small intestine is about 6.0. pK= 3.5 H uncharged form charged form The form can cross the lipid bilayer more effectively and thus, majority of the aspirin will be absorbed into the bloodstream through the uncharged; small intestine O charged; small intestine O uncharged; stomach lining charged; stomach lining
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