Arsenate (AsO43-) has been used as a poison since ancient times. It disturbs glycolysis by interfering with the phosphoglycerate kinase reaction. How does arsenate interfere with that reaction in molecular terms, and why is this interference toxic to the cell?
Catalysis and Enzymatic Reactions
Catalysis is the kind of chemical reaction in which the rate (speed) of a reaction is enhanced by the catalyst which is not consumed during the process of reaction and afterward it is removed when the catalyst is not used to make up the impurity in the product. The enzymatic reaction is the reaction that is catalyzed via enzymes.
Lock And Key Model
The lock-and-key model is used to describe the catalytic enzyme activity, based on the interaction between enzyme and substrate. This model considers the lock as an enzyme and the key as a substrate to explain this model. The concept of how a unique distinct key only can have the access to open a particular lock resembles how the specific substrate can only fit into the particular active site of the enzyme. This is significant in understanding the intermolecular interaction between proteins and plays a vital role in drug interaction.
Arsenate (AsO43-) has been used as a poison since ancient times. It disturbs glycolysis by interfering with the phosphoglycerate kinase reaction. How does arsenate interfere with that reaction in molecular terms, and why is this interference toxic to the cell?
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