You are called in as a consult for a patient who suffers from acidosis. Urine levels of both lactic acid and isocitric acid are elevated. Mitochondria isolated from the patient’s fibroblasts oxidize pyruvate very slowly whereas α-ketoglutarate and malate are oxidized normally. a. At what enzyme would you predict the patient has a defect? b. Why? What evidence do you have to choose that enzyme? c. How do you account for the increase in lactic acid?

Q: Which statement concerning the effectiveness of enzymes is NOT true? Select one: An enzyme may not…

A: Enzymes are catalysts which are proteins. They lower the activation energy of a reaction by binding…

Q: 32. Although most enzymes are quite specific, they can catalyze side reactions with compounds that…

A: GAPDH is primarily known for its role in the glycolytic pathway, where it catalyzes the oxidative…

Q: 11. An enzyme has no activity at an extremely low pH. What could be an explanation for this…

A: At low pH acidic conditions are dominant and the following changes might occurThe more acidic group…

Q: 1. Explain what happens to the velocity in the following scenarios. a. More substrate is added when…

A: Since you have posted multiple questions, we can solve only the first question for you according to…

Q: 8. Write the products for the following hydrolysis or condensation reactions. a. HgC. NH b. H,0

A:

Q: Explain a phase G1, S, and G2 from mitosis.

A: The G1, S and G2 phase from mitosis is explained below:

Q: Using the same format as below draw the ructure of compound X in the following metabolic reaction.…

A: Transamination reaction: A chemical reaction that transfers an amino group (NH2) to a keto acid to…

Q: 6. State the type of inhibition in the following: a. The inhibitor has a structure that is similar…

A: 6. a)The inhibitor has a structure that is similar to substrate, As they have a structure resembling…

Q: 7. which type of cross-link involves interactions between two cysteine amino acids? 8. Which type of…

A: Two same or different amino acids may cross link with each other via covalent bond with an…

Q: A non-substrate molecule binds to an enzyme at the active site, causing the enzyme to stop working…

A: A non-substrate molecules binds to an enzyme at the active site causing the enzyme to stop working…

Q: Fill in the Blanks Type your answers in all of the blanks and submit X, Xº 22- COOH (=O CH₂ CH₂ COOH…

A: Given compound is formed during TCA cycle i.e. tricarboxylic acid cycle.This cycle also known as…

Q: Which enzyme would catalyze the reaction illustrated below? triacylglycerol + 3H2O → glycerol + 3…

A: The reaction is  triacylglycerol + 3H2O → glycerol + 3 fatty acids

Q: ve Site Models 27) In the active site, there are two models of substrate binding. What is described…

A: 27.Each type of enzyme has a unique structure that enables a specific reaction. This means that for…

Q: 10. For the chart of enzyme activity: a. At what temperature does this enzyme have the highest…

A: Analysis-  Enzyme activity which indicate the rate of reaction catalysed by that enzyme. Enzyme…

Q: 17. There are several types of enzyme regulators that act as either positive or negative controls.…

A: We are to find out which kind of regulator is shown in the figure, positive or negative.

Q: What is NOT a feature of allosteric enzymes? O They have a sigmoidal dependence of the reaction…

A:

Q: Noncovalent bonds are too weak to influence the native structure of proteins. Select one: a.

A: Proteins are made up of number of small units called amino acids. These amino acids are attached to…

Q: Is the above reaction endergonic or exergonic? Which letter is AG of the reaction? Which letter is…

A: A reaction profile diagram is a theoretical representation of a chemical reaction as an energetic…

Q: A. Given the information in the image, what type of inhibitor would Sulfanilamide be?  B. Sketch out…

A: Enzymes are substances that are capable of enhancing the rate of a reaction and hence act as…

Q: A transition-state analog ____. Select one: a. resembles the transition-state structure of the…

A: Transition state analogues are defined as a chemical species which resembles the transition state of…

Q: Q8 In which reaction mixture(s) did hydrolysis of starch occur?

A: Since you have asked multiple questions questions, we will solve the first question for you. If you…

Q: What term is used to describe a species which affects the functioning of an allosteric enzyme?   a.…

A: An allosteric inhibitor by binding to allosteric site changes the protein conformation in active…

Q: Which of the following is NOT a property of enzymes? A) Their activity depends on the 3-dimensional…

A: The correct statements regarding enzymes are as follows: A) Three-dimensional structure dependence:…

Q: 4.     The amino acid Asp189 lies at the base of the substrate specificity pocket in the enzyme…

A: Trypsin, a serine protease, has substrate specificity owing to the presence of Asp189 at the bottom…

Vitamins and Coenzymes

A class of organic compounds needed in the human body for normal activities is known as vitamins. They are characterized into two parts depending upon their solubility in water. They can act as coenzymes, cofactors, or prosthetic groups for enzymes.