An amidation reagent is 0.17 M in HOBt and 0.017 M in DMAP. Given that the pKa of HOBt is 4.6 and the pKa of DMAP-H+ is 9.6, is the DMAP present in its protonated or deprotonated form? Explain your reasoning

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A: This can be explaine on the basis of the geometric representation of maleic acid and fumaric acid.

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Q: 그 I-O H 2 N H D+1 CH, CH,,

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A: Given,

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A: Answer: Hey, Since you have posted a question with multiple sub-parts, we will solve first three…

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Q: How is the Km value influenced in the presence of the inhibitor?

A: The Km value is the concentration of substrate that provides the rate halfway to maximum velocity…

Q: Biotin has a single ionizable group with a pKa of 4.5. If you dissolved biotin in an aqueous…

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A: The difference between anhydride and mixed anhydride bonds is given in the table below:

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Q: Match the pKa values to the appropriate compound. pKa values: 0.28, 1.24, 2.66, 2.86, and 3.12.…

A:

Q: Why does methyl orange have a lower pKa value (pKa~3.5) than methyl red (pKa ~5.1)?

A: We are to discuss why pKa value of methyl orange is lower than that of methyl red.

Q: 10) Can H₂PO, exist with H₂PO, in a mixture? What about H,PO, and HPO,?? What about H,PO, and PO,³?

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A:

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A:

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Q: What is the ratio of base [A] to acid [HA] at pH 4, 5, 6 and 7 for an acid with a pka of 6?

A:

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A: We would use Henderson Hasselbalch equation to calculate the ratio.

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Q: (a)Draw Histidine in all its protonated form and include the pKa's where appropriate. (b) Calculate…

A: Given Values: pK1 = 1.8  pK2 = 9.2 pKR = 6.0

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Q: How can the Michaelis constant (Km) be identified and used to represent the affinity between the…

A: The correct answer is given below

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Q: Trypsin is a serine protease that has a KM of 15 mM. At an initial substrate concentration of 250 µM…

A: Given that, for a serine protease trypsin The Michaelis-Menten constant is KM = 15 mM = 15×10-3 M,…