All the dehydrogenases of glycolysis and the citric acid cycle use NAD+ (?′°E′° for NAD+/NADH is −0.32 V−0.32 V) as electron acceptor except succinate dehydrogenase, which uses covalently‑bound FAD (?′°E′° for FAD/FADH2 in this enzyme is 0.050 V).0.050 V). The ?′°E′° value for fumarate/succinate is 0.031 V.0.031 V.a)Calculate the Δ?′°Δ⁢G′° value for the oxidation of succinate using NAD+.b)Calculate the Δ?′°Δ⁢G′° value for the oxidation of succinate using covalently‑bound FAD.

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Answered: All the dehydrogenases of glycolysis…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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All the dehydrogenases of glycolysis and the citric acid cycle use NAD⁺ (?′°E′° for NAD⁺/NADH is −0.32 V−0.32 V) as electron acceptor except succinate dehydrogenase, which uses covalently‑bound FAD (?′°E′° for FAD/FADH₂ in this enzyme is 0.050 V).0.050 V). The ?′°E′° value for fumarate/succinate is 0.031 V.0.031 V.

a)Calculate the Δ?′°Δ⁢G′° value for the oxidation of succinate using NAD⁺.

b)Calculate the Δ?′°Δ⁢G′° value for the oxidation of succinate using covalently‑bound FAD.

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