All eukaryotes possess a surveillance pathway referred to asnon-sense-mediated mRNA decay (NMD). Its principalfunction is to eliminate mRNA transcripts with prematurestop codons. Such faulty transcripts are detected duringtranslation and subsequently destroyed by removal of the 5′cap followed by degradation by a nuclease. Describe howpremature stop codons are detected and what type of errorcauses them.

Biology (MindTap Course List)
11th Edition
ISBN:9781337392938
Author:Eldra Solomon, Charles Martin, Diana W. Martin, Linda R. Berg
Publisher:Eldra Solomon, Charles Martin, Diana W. Martin, Linda R. Berg
Chapter14: Gene Regulation
Section14.3: Gene Regulation In Eukaryotic Cells
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All eukaryotes possess a surveillance pathway referred to as
non-sense-mediated mRNA decay (NMD). Its principal
function is to eliminate mRNA transcripts with premature
stop codons. Such faulty transcripts are detected during
translation and subsequently destroyed by removal of the 5′
cap followed by degradation by a nuclease. Describe how
premature stop codons are detected and what type of error
causes them.

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