All amino acids have two ionizable functional groups: an a-amino group (average pK₁ of 9.4) and an o-carboxylic acid group (average pK₁ of 2.2). Lysine also has an ionizable side chain (R group) with a pK, of about 10.5. One of the possible ionization states of lysine is shown in the image. || H₂N-CH-C-OH I CH₂ 1 CH₂ T Incorrect CH₂ 1 CH₂ +1 NH3 At what pH would the structure be the predominant ionization state? Consider the ionization state of all three of the functional groups. 10.5 The protonated form of the R group of lysine is shown in the structure. The ratio of the charged (protonated) form to the deprotonated form depends on the pK₁ of the R group and the pH of the solution. Select all the pH values at which the charged form of the R group would predominate.

Biochemistry
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Chapter1: Biochemistry: An Evolving Science
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Select all the pH values at which the charged form of the R group would predominate.
* 2.2
* 12.4
* 6.2
* 10.5

All amino acids have two ionizable functional groups: an α-amino group (average pK₁ of 9.4) and an α-carboxylic acid group
(average pK₂ of 2.2). Lysine also has an ionizable side chain (R group) with a pK, of about 10.5. One of the possible ionization
states of lysine is shown in the image.
H₂N-CH-C-OH
I
Incorrect
CH₂
CH₂
CH₂
T
CH₂
+I
||
NH3
At what pH would the structure be the predominant ionization state? Consider the ionization state of all three of the
functional groups.
10.5
The protonated form of the R group of lysine is shown in the structure. The ratio of the charged (protonated) form to the
deprotonated form depends on the pK₁ of the R group and the pH of the solution.
Select all the pH values at which the charged form of the R group would predominate.
Transcribed Image Text:All amino acids have two ionizable functional groups: an α-amino group (average pK₁ of 9.4) and an α-carboxylic acid group (average pK₂ of 2.2). Lysine also has an ionizable side chain (R group) with a pK, of about 10.5. One of the possible ionization states of lysine is shown in the image. H₂N-CH-C-OH I Incorrect CH₂ CH₂ CH₂ T CH₂ +I || NH3 At what pH would the structure be the predominant ionization state? Consider the ionization state of all three of the functional groups. 10.5 The protonated form of the R group of lysine is shown in the structure. The ratio of the charged (protonated) form to the deprotonated form depends on the pK₁ of the R group and the pH of the solution. Select all the pH values at which the charged form of the R group would predominate.
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