acetolactate CH + CH3CH synthase CH + CO2 ТР НО CH,CH3 a-ketobutyrate a-aceto-a-hydroxybutyrate

Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
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Acetolactate synthase transfers the acyl group of pyruvate to a-ketobutyrate. This is the first step in the biosynthesis of the amino acid isoleucine. Propose a mechanism for this reaction.

acetolactate
CH
+ CH3CH
synthase
CH
+ CO2
ТР
НО
CH,CH3
a-ketobutyrate
a-aceto-a-hydroxybutyrate
Transcribed Image Text:acetolactate CH + CH3CH synthase CH + CO2 ТР НО CH,CH3 a-ketobutyrate a-aceto-a-hydroxybutyrate
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