(a) Why did they choose this two-stage approach? (b) How did they cause the cells to shift from a growth phase to a quiescent (non-growth) phase? (c)Please discuss which factors influence the choice of bioreactor design for optimal antibody production
According to Research and Development department analysisresults, it was concluded that a two-stage control strategy wasoptimal for antibody production. In the first stage, conditions wereoptimized for cell growth. In the second stage, conditions werechanged to halt cell growth. Please answer the following questions in 1-2 sentences.
(a) Why did they choose this two-stage approach?
(b) How did they cause the cells to shift from a growth phase to a quiescent (non-growth) phase?
(c)Please discuss which factors influence the choice of bioreactor design for optimal antibody production
(Hint: The production of antibody which is anchorage-dependentsystems from continuous cell lines can be accomplished usingseveral bioreactor configurations, each of which was designed tosatisfy differing operational, product quality, economic, andproduction scale requirements.)
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