A study was conducted [15] concerning the effect of calcium supplementation on bone loss among postmenopausal women. Women were randomized to (1) estrogen cream and calcium placebo (n = 15), (2) placebo estrogen cream and 2000 mg/day of calcium (n = 15), or (3) placebo estrogen cream and calcium placebo (n = 13). Subjects were seen every 3 months for a 2-year period. The rate of bone loss was computed for each woman and expressed as a percentage of the initial bone mass. The results are shown in Table 12.36 12.31 What test can be used to compare the mean rate of bone loss in the three groups? 12.32 Implement the test in Problem 12.31, and report a p-value. 12.33 Identify which pairs of groups are different from each other, using both t tests and the method of multiple comparisons. Report a p-value for each pair of treatment groups.
A study was conducted [15] concerning the effect of calcium supplementation on bone loss among postmenopausal women. Women were randomized to (1) estrogen cream and calcium placebo (n = 15), (2) placebo estrogen cream and 2000 mg/day of calcium (n = 15), or (3) placebo estrogen cream and calcium placebo (n = 13). Subjects were seen every 3 months for a 2-year period. The rate of bone loss was computed for each woman and expressed as a percentage of the initial bone mass. The results are shown in Table 12.36
12.31 What test can be used to compare the mean rate of bone loss in the three groups?
12.32 Implement the test in Problem 12.31, and report a p-value.
12.33 Identify which pairs of groups are different from each other, using both t tests and the method of multiple comparisons. Report a p-value for each pair of treatment groups.
12.34 Which methodology do you think is more appropriate in Problem 12.33?
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