A receptor-ligand complex has a dissociation constant of Kd = 20 nM. The rate of receptor-ligand complex formation with an added ligand concentration of 10 µM is 5 × 10³ s-¹. What is the value of the reverse rate constant, k_₁? S

Biochemistry
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Chapter1: Biochemistry: An Evolving Science
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A receptor-ligand complex has a dissociation constant of Ka 20 nM. The rate of receptor-ligand complex formation with an
added ligand concentration of 10 µM is 5 × 10³ s¯¹. What is the value of the reverse rate constant, k_₁?
k_1 =
100 ×10
Incorrect
-6
S-1
Transcribed Image Text:= A receptor-ligand complex has a dissociation constant of Ka 20 nM. The rate of receptor-ligand complex formation with an added ligand concentration of 10 µM is 5 × 10³ s¯¹. What is the value of the reverse rate constant, k_₁? k_1 = 100 ×10 Incorrect -6 S-1
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You have not correctly calculated the
value of the reverse rate constant.
To begin, calculate the value of k₁ by
dividing the rate of receptor-ligand
complex formation (the rate of the
forward reaction) by the
ligand concentration.
k₁ =
rate forward
[L]
X
Then, calculate the value of the reverse
rate constant, k_1, by multiplying the
dissociation constant, Kd, and the
forward rate constant, k₁.
k_1 = Kakı
Transcribed Image Text:Feedback You have not correctly calculated the value of the reverse rate constant. To begin, calculate the value of k₁ by dividing the rate of receptor-ligand complex formation (the rate of the forward reaction) by the ligand concentration. k₁ = rate forward [L] X Then, calculate the value of the reverse rate constant, k_1, by multiplying the dissociation constant, Kd, and the forward rate constant, k₁. k_1 = Kakı
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