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A physician wants to administer an anesthetic agent at a rate of 5 mg/h by IV infusion. The elimination rate constant is 0.2 h¹ and volume of distribution is 20 L. a. How long will it take to reach a drug concentration of 1 µg/ml? b. How long will it take to reach steady state? c. What loading dose should be recommended if the doctor wants the drug concentration to reach 1.25 µg/ml immediately? What is the concentration of a drug 3 hours after administration of a loading dose of 10 mg and the simultaneous infusion of 2 mg/h? The drug has a half-life of 3 h and a volume of distribution of 10 L? A patient was infused for 12 h with a drug (k= 0.4 h; Vd- 15 L) at a rate of 5 mg/h. What are the concentrations of the drug at 1, 2, 8, 10, 14, and 16 hours since the start of the infusion? Given the following drug concentrations determine k, Va, CL and half-life for a drug infused at a rate of 200 mg/h for 8 hours.

A physician wants to administer an anesthetic agent at a rate of 5 mg/h by IV infusion. The elimination rate constant is 0.2 h¹ and volume of distribution is 20 L. a. How long will it take to reach a drug concentration of 1 µg/ml? b. How long will it take to reach steady state? c. What loading dose should be recommended if the doctor wants the drug concentration to reach 1.25 µg/ml immediately? What is the concentration of a drug 3 hours after administration of a loading dose of 10 mg and the simultaneous infusion of 2 mg/h? The drug has a half-life of 3 h and a volume of distribution of 10 L? A patient was infused for 12 h with a drug (k= 0.4 h; Vd- 15 L) at a rate of 5 mg/h. What are the concentrations of the drug at 1, 2, 8, 10, 14, and 16 hours since the start of the infusion? Given the following drug concentrations determine k, Va, CL and half-life for a drug infused at a rate of 200 mg/h for 8 hours.

Phlebotomy Essentials
Phlebotomy Essentials
6th Edition
ISBN:9781451194524
Author:Ruth McCall, Cathee M. Tankersley MT(ASCP)
Publisher:Ruth McCall, Cathee M. Tankersley MT(ASCP)
Chapter1: Phlebotomy: Past And Present And The Healthcare Setting
Section: Chapter Questions
Problem 1SRQ
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1. 2. 3. 4. A physician wants to administer an anesthetic agent at a rate of 5 mg/h by IV infusion. The elimination rate constant is 0.2 h¹ and volume of distribution is 20 L. a. How long will it take to reach a drug concentration of 1 µg/ml? b. How long will it take to reach steady state? c. What loading dose should be recommended if the doctor wants the drug concentration to reach 1.25 µg/ml immediately? What is the concentration of a drug 3 hours after administration of a loading dose of 10 mg and the simultaneous infusion of 2 mg/h? The drug has a half-life of 3 h and a volume of distribution of 10 L? A patient was infused for 12 h with a drug (k= 0.4 h¹; Vd= 15L) at a rate of 5 mg/h. What are the concentrations of the drug at 1, 2, 8, 10, 14, and 16 hours since the start of the infusion? Given the following drug concentrations determine k, V₁, CL and half-life for a drug infused at a rate of 200 mg/h for 8 hours. Time(hr) 1 2 4 8 9 10 14 Drug Concentration(mg/L) 27.50 40 48 50 22.40 10 0.40
Transcribed Image Text:1. 2. 3. 4. A physician wants to administer an anesthetic agent at a rate of 5 mg/h by IV infusion. The elimination rate constant is 0.2 h¹ and volume of distribution is 20 L. a. How long will it take to reach a drug concentration of 1 µg/ml? b. How long will it take to reach steady state? c. What loading dose should be recommended if the doctor wants the drug concentration to reach 1.25 µg/ml immediately? What is the concentration of a drug 3 hours after administration of a loading dose of 10 mg and the simultaneous infusion of 2 mg/h? The drug has a half-life of 3 h and a volume of distribution of 10 L? A patient was infused for 12 h with a drug (k= 0.4 h¹; Vd= 15L) at a rate of 5 mg/h. What are the concentrations of the drug at 1, 2, 8, 10, 14, and 16 hours since the start of the infusion? Given the following drug concentrations determine k, V₁, CL and half-life for a drug infused at a rate of 200 mg/h for 8 hours. Time(hr) 1 2 4 8 9 10 14 Drug Concentration(mg/L) 27.50 40 48 50 22.40 10 0.40
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