drug is risperidone Briefly discuss whether the value of the volume of distribution applies to all routes of administration and comment on the distribution of your allocated drug. Calculate how long it takes to a) eliminate 95% of a single dose after absorption, and b) to reach a steady-state blood concentration after repeated dosing at regular half-life intervals. Provide the equations used. Calculate the systemic clearance of your allocated drug. Provide the equation used. Discuss whether this clearance value applies to all routes of administration. Briefly discuss how administering your allocated drug with each of the medicines/foods below would affect the pharmacokinetics and risks of administering your allocated drug: the antibiotic rifampicin, classified as a “potent inducer of CYP3A4” in the AMH; the antibiotic ketoconazole, classified as a “potent inhibitor of CYP3A4” in the AMH. the herbal medicine St John’s wort, is classified as an “inducer of CYP3A4” in the AMH; grapefruit juice, is classified as an “inhibitor of CYP3A4” in the AMH.

drug is risperidone Briefly discuss whether the value of the volume of distribution applies to all routes of administration and comment on the distribution of your allocated drug. Calculate how long it takes to a) eliminate 95% of a single dose after absorption, and b) to reach a steady-state blood concentration after repeated dosing at regular half-life intervals. Provide the equations used. Calculate the systemic clearance of your allocated drug. Provide the equation used. Discuss whether this clearance value applies to all routes of administration. Briefly discuss how administering your allocated drug with each of the medicines/foods below would affect the pharmacokinetics and risks of administering your allocated drug: the antibiotic rifampicin, classified as a “potent inducer of CYP3A4” in the AMH; the antibiotic ketoconazole, classified as a “potent inhibitor of CYP3A4” in the AMH. the herbal medicine St John’s wort, is classified as an “inducer of CYP3A4” in the AMH; grapefruit juice, is classified as an “inhibitor of CYP3A4” in the AMH.