Give two COX inhibitors. Why does COX inhibitors act as blood thinner, and antipyretic drugs?
Give two COX inhibitors. Why does COX inhibitors act as blood thinner, and antipyretic drugs?
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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Question
Give two COX inhibitors. Why does COX inhibitors act as blood thinner, and antipyretic drugs?
Expert Solution
Step 1
Cyclooxygenase is an enzyme present in the blood vessels and muscle tissues, primarily involved in the sensation of pain. The enzyme is involved in the catalysis of the rate-limiting step in the conversion of arachidonic acid to prostaglandins.
The prostaglandins are responsible for pain in the sites of injury, inflammation, or infection. Cyclooxygenase (COX) inhibitors reduce pain by inhibiting the biosynthesis of prostaglandins from arachidonic acid.
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