a deaminating agent5-BU isthat can base-pair ike cytosine or likeIf 5-BU iscytosineIncorporated in place ofit causes an AT.to-GC transition. If 5-BU is incorporatedguanineinto DNA in place ofit causes a GC-10-AT transition.uracilNitrous acid isNitrous acid convertstowhich willa base analogcause a CG-to-TA transition. Nitrous acid can also converttowhich will cause an AT-10-GC ransition,thymidinehypoxanthinecytidineadeninethymine

5-Bromo Uracil and nitrous acid are mutagenic agents. It means both of these agents cause mutation…

Answered: a deaminating agent 5-BU is that can…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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Similar questions

The enzymes GICNAC phosphotrasnferase is a key enzyme involved in the transporting of proteins from the trans-Golgi to the lysozyme. In addition to the catalytic function of the enzyme that involves certain sugars, what is the second critical function of this enzyme? O It recognizes internal signal sequences found on lysozyme-targeted proteins. O It drives the binding of a phosphorylated GlcNac group onto a mannose residue. O It facilitates the reversible binding of specific proteins to the M6P receptor O In is essential for the recruitment of clathrin triskelions to the budding vesicle.
Consider the mechanism of the enzyme RNase:  What would happen to the Km (i.e., would it increase, decrease, or stay the same) if the his12 was mutated to a lysine? Explain.  What would happen to the Kcat (i.e., would it increase, decrease, or stay the same) if the his12 was mutated to a valine? Explain.
Certain hormones, such as epinephrine, can increase the levels ofcAMP within cells. Let’s suppose you pretreat cells with or withoutepinephrine and then prepare a cell extract that contains theCREB protein.You then use an electrophoretic mobility shift assay to analyzethe ability of the CREB protein to bind to a DNA fragmentcontaining a cAMP response element (CRE). Describe what theexpected results would be.
Genes involved in DNA to protein route are highly conserved in comparison to genes of enzymes that catalyze steps in metabolic pathways individually. What could be the reason for this?
The mutation in hemoglobin at B82 Lys → Asp results in lowered O,-binding affinity compared to normal hemoglobin. B82 is one of the residues that lines the 2,3-BPG binding site (see Figure 7.29; B82 is adjacent to His143). Based on the location of this residue and the differences between Lys and Asp, sug- gest a rationale for the observed reduction in Oz-binding affinity.
In E. Coli, β ans β' are subunits that clamps on to the DNA strand whereas σ is directly involved with finding and binding to promotor and initiation sequences. true or false The σ subunits (1-4) are associated with channels in β and β'. true or false
Phosphorylation of elf-2 regulates eukaryotic protein synthesis initiation by inhibiting formation of the pre-initiation complex. Select one: O True O False
Match the protein on the left with the type of activation of that protein on the right STAT Smad PKA Ras NFKB Nuclear receptor [Choose] [Choose] GTP binding serine phosphorylation Interaction with Galpha Cleavage by y-secretase destruction of a protein by proteasome tyrosine phosphorylation second messenger ligand binding [Choose] [Choose] [Choose]
In the formation of the initiation complex, which protein wraps around the DNA double helix forming a platform on which the remainder of the initiation complex can be assembled? TATA GTF TBP Pol II
Given the following diagram of how protein AWESOME1 binds to it's target DNA, describe the potential effects of each of the 5 mutations shown below. The wild-type sequence of a helix #1 is also shown in the blue box, and all the mutations are in helix #1 (see numbers for identifying particular residues). a helix #1 R(1)-V-I-L-Y-F-W-I-M-Y-F-S-H-Y-W-R(16) #1 Predict the consequence of the following mutations: 1) Arg(1) to Glu 2) Arg(1) to Ala 3) Phe(6) to lle 4) Trp(7) to Phe 5) Met(9) to Pro in
Explain the signifi cance of the observation that peptides such as fMet-Leu-Phe “activate” the phagocytotic (particle-engulfi ng) functions of mammalian leukocytes (white blood cells).
a change that decreases the rate of hydrolysis of GTP by Ras a change that increases the affinity of Ras for GDP a change that decreases the affinity of Ras for GTP O a change that prevents Ras from being made

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