(a) Alternative splicing DNA Intron 1 Intron 2 Exon 1 Exon 2 Exon 3 Transcription 3' cleavage site Pre-MRNA 5' Exon 1 ΕonΣ ΕΚΟΠΕ 3' 3' cleavage and polyadenylation 5' Exon 1 Exon 2 ΕΚΟΠΕΙΑΑΛΑA 3 Either two introns are removed to yield one MRNA... ..or two introns and exon 2 are removed to yield a different mRNA. Alternative RNA splicing MRNA 5' Exon 1 Exon 2 Exon 3 AAAAA 3' 5' Exon 1 Exon 3 AAAAA 3' Gron 2 Intron 2 Intron 1, exon 2, and intron 2 Intron 1
Gene Interactions
When the expression of a single trait is influenced by two or more different non-allelic genes, it is termed as genetic interaction. According to Mendel's law of inheritance, each gene functions in its own way and does not depend on the function of another gene, i.e., a single gene controls each of seven characteristics considered, but the complex contribution of many different genes determine many traits of an organism.
Gene Expression
Gene expression is a process by which the instructions present in deoxyribonucleic acid (DNA) are converted into useful molecules such as proteins, and functional messenger ribonucleic (mRNA) molecules in the case of non-protein-coding genes.
Suppose that a 20-bp deletion occurs in the middle of exon 2 of the gene depicted in Figure 14.12a. What will be the likely effect of this deletion in the proteins produced by alternative splicing?
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