(a) A retrovirus inserts its RNA into the cel: the wiral RNA undergoes Viral RNA reverse transcription and inserts into the host chromosome nest to a protooncogene. Reverse transcription Host chromosome Provirus Proto oncogene Viral reproduction When the virus reproduces, the proto-oncogene is incorporated into the virus In repeated rounds of viral infection and Repeated rounds of infection and reproduction, the proto-oncogene becomes rearranged or mutated or both. reproduction Viral RNA Reverse transcription producing an oncogene that inserted back into the hast chromosome. Host chromosome Mutation Provirus Oncogene (b) A retrovirus infects a cell... 2.and the provirus 3 The strong viral promoter stimulates over- expression of the inserts near a proto-oncogene. proto-oncogene. Strong viral promoter Provirus / Proto-oncogene Over- expression MRNA 23.14 Retroviruses can cause cancer by (a) mutating or rearranging proto- oncogenes or (b) inserting strong promoters near proto-oncogenes.

Human Anatomy & Physiology (11th Edition)
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ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
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Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Assume that the provirus in Figure 23.14 inserts just upstream of a
tumor-suppressor gene. Would this insertion be likely to cause cancer?
Why or why not?

(a)
A retrovirus inserts
its RNA into the cel:
the wiral RNA undergoes
Viral
RNA
reverse transcription
and inserts into the
host chromosome nest
to a protooncogene.
Reverse
transcription
Host
chromosome
Provirus
Proto
oncogene
Viral
reproduction
When the virus reproduces,
the proto-oncogene is
incorporated into the virus
In repeated rounds of
viral infection and
Repeated rounds
of infection and
reproduction, the
proto-oncogene
becomes rearranged
or mutated or both.
reproduction
Viral
RNA
Reverse
transcription
producing an
oncogene that
inserted back into
the hast chromosome.
Host
chromosome
Mutation
Provirus Oncogene
Transcribed Image Text:(a) A retrovirus inserts its RNA into the cel: the wiral RNA undergoes Viral RNA reverse transcription and inserts into the host chromosome nest to a protooncogene. Reverse transcription Host chromosome Provirus Proto oncogene Viral reproduction When the virus reproduces, the proto-oncogene is incorporated into the virus In repeated rounds of viral infection and Repeated rounds of infection and reproduction, the proto-oncogene becomes rearranged or mutated or both. reproduction Viral RNA Reverse transcription producing an oncogene that inserted back into the hast chromosome. Host chromosome Mutation Provirus Oncogene
(b)
A retrovirus
infects a cell...
2.and the provirus
3 The strong viral
promoter
stimulates over-
expression of the
inserts near a
proto-oncogene.
proto-oncogene.
Strong viral
promoter
Provirus /
Proto-oncogene
Over-
expression
MRNA
23.14 Retroviruses can cause cancer by (a) mutating or rearranging proto-
oncogenes or (b) inserting strong promoters near proto-oncogenes.
Transcribed Image Text:(b) A retrovirus infects a cell... 2.and the provirus 3 The strong viral promoter stimulates over- expression of the inserts near a proto-oncogene. proto-oncogene. Strong viral promoter Provirus / Proto-oncogene Over- expression MRNA 23.14 Retroviruses can cause cancer by (a) mutating or rearranging proto- oncogenes or (b) inserting strong promoters near proto-oncogenes.
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