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A 160 residue polytopic integral plasma membrane protein has the following sequence at its N-terminus. The amino terminal Ser is located inside the cytoplasm. Amino acids 11- 14 are localized outside the cell. N-¹Ser-Tyr-Leu-Gln-Ile-Arg-Phe-Asn-Leu-Lys-11 Gly-Pro-Gly-Ser-15 Glu-Phe-Gln-Leu-Asp- Ile-His-Leu-23 Ser-Gly-Gly Carefully analyze the sequence. (a) What do you predict for the overall tertiary structure of the entire 160 residue protein? (b) Give at least three reasons for your prediction. Ruling out alternatives, with proper logic, can count as a reason.

A 160 residue polytopic integral plasma membrane protein has the following sequence at its N-terminus. The amino terminal Ser is located inside the cytoplasm. Amino acids 11- 14 are localized outside the cell. N-¹Ser-Tyr-Leu-Gln-Ile-Arg-Phe-Asn-Leu-Lys-11 Gly-Pro-Gly-Ser-15 Glu-Phe-Gln-Leu-Asp- Ile-His-Leu-23 Ser-Gly-Gly Carefully analyze the sequence. (a) What do you predict for the overall tertiary structure of the entire 160 residue protein? (b) Give at least three reasons for your prediction. Ruling out alternatives, with proper logic, can count as a reason.

Biochemistry
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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A 160 residue polytopic integral plasma membrane protein has the following sequence at its N-terminus. The amino terminal Ser is located inside the cytoplasm. Amino acids 11- 14 are localized outside the cell. N-¹Ser-Tyr-Leu-Gln-Ile-Arg-Phe-Asn-Leu-Lys-11 Gly-Pro-Gly-Ser-15 Glu-Phe-Gln-Leu-Asp- Ile-His-Leu-23 Ser-Gly-Gly Carefully analyze the sequence. (a) What do you predict for the overall tertiary structure of the entire 160 residue protein? (b) Give at least three reasons for your prediction. Ruling out alternatives, with proper logic, can count as a reason.
Transcribed Image Text:A 160 residue polytopic integral plasma membrane protein has the following sequence at its N-terminus. The amino terminal Ser is located inside the cytoplasm. Amino acids 11- 14 are localized outside the cell. N-¹Ser-Tyr-Leu-Gln-Ile-Arg-Phe-Asn-Leu-Lys-11 Gly-Pro-Gly-Ser-15 Glu-Phe-Gln-Leu-Asp- Ile-His-Leu-23 Ser-Gly-Gly Carefully analyze the sequence. (a) What do you predict for the overall tertiary structure of the entire 160 residue protein? (b) Give at least three reasons for your prediction. Ruling out alternatives, with proper logic, can count as a reason.
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