7. Substitution reaction and mechanism. Please identify the product of the following reaction. Draw the arrow pushing mechanism to explain how the product forms (20 pts) OH Br (Heat) Mechanism: Product(s): OH
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- organic chemistry help Fill in the missing starting materials, reagents, or major products of each reactionThe following reaction can be described by a THREE step mechanism. A drawing of the energy diagram for this reaction is shown below. OH H, SO4 В A Reaction coordinate (i) Write out the three steps in this mechanism. For each step, draw structures for the reactants and products and curved arrows to show bonds formed and bonds broken. (ii) Indicate which of the drawings in your mechanism corresponds to points A, B and C on the energy diagram. Draw the structure of the MAJOR product in the following reaction and an arrow pushing reaction mechanism to showhow the product is formed. H;O+ Potential energy#16d. Provide the missing reactants, reagents, or products for the following reaction sequences below.
- 1. Predict the product and provide the mechanism for the following reversible nucleophilic addition. NaOH in H₂O 2. Predict the product and provide the mechanism for the following reversible nucleophilic addition. H2SO4 (cat) H EtOH45) Provide the expected mechanism for the following reaction. Please show all intermediates and use arrows to show the movement of electrons (you do not have to show transition states). (1 pt) ii CI NaOH (2 equiv)
- Answer the questions below with reference to the reaction shown here: Meo. `OH 2 Meo AICI3 (a) The reaction involves the initial formation of an "acylium ion" from 2: draw the mechanism for the formation of this ion. (b) Draw the structure of the intermediate formed when the acylium ion reacts with compound 1, and then show by means of curved arrows how this intermediate is transformed to the final product 3. (You do not need to show all the resonance forms of the intermediate.) Explain why the substitution takes place ortho to the OMe (c) substituent and not ortho to the methyl substituent.Draw the two reactants used to form the following compound, label the nucleophile and the electrophile, and using arrows show the points of attack of the nucleophile on the electrophile that enables the formation of the heterocyclic product.Below is a short reaction sequence. Provide the structure of the two missing organic compounds.
- Draw the organic product you would expect to isolate from the nucleophilic substitution reaction between the molecules shown. Note: You do not need to draw any of the side products of the reaction, only the substitution product. D xx + H₂O + X Click and drag to start drawing a structure.Draw the mechanism for the reaction of an alkyl halide with sodium azide followed by reduction. Complete the mechanism of the initial step of the reaction, then identify the key intermediate and the product. Step 1: Draw curved arrows. o z + Na + || : z: I Step 2: Complete the intermediate. Na +3. SN2 reactions are useful in the synthesis of many pharmaceutical compounds. The antiviral agent acyclovir can be prepared using an S№2 reaction as shown below followed by a hydrolysis reaction. The hydrolysis reaction will be discussed in CHEM 40B. R'RN A + B SN2 R'RN ELECTROPHILE: من مهمه NUCLEOPHILE: Identify which molecule (A or B) would serve as the electrophile and which would serve as the nucleophile in the S№2 reaction. Place your responses in the box below. Connections to biology The amino acid cysteine is one of the common building blocks of proteins that contains the thiol (SH) functional group. The reactivity of the thiol group allows researchers to connect various molecules to proteins, a process known as labeling. For example, it is possible to connect fluorescent probes that allow us to trace the fate of proteins in the cell. H SH O Cysteine amino acid within a protein chain sa acyclovir LG H₂N S OH H O Cysteine amino acid labeled with electrophilic probe…