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![65. The effectiveness of metronidazole, useful in treating active amebic infection, is dependent on which of the following?
CA) Activation of the drug by inflammatory mediators
OB) Anaerobic reduction of the drug to its active form by the parasite
C) Presence of a parasite-specific DNA topoisomerase
CD) Selective depletion of intracellular folate stores](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2Faf50ae2b-f7f6-4ca9-a7f0-dedcf10368cd%2F1331f0bb-63a9-455d-9054-a43cc7a5b1df%2Fyk8drtc_processed.jpeg&w=3840&q=75)
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- Many antibiotics used in modern medicine are compounds made by fungi that inhibit bacterial protein synthesis. Describe the specific effect of the following antimicrobial drugs: (i) Tetracycline (ii) Puromycin (iii) Alpha-AmanitinWhich one of the following categories for antibacterial agents is most likely to have toxic side effects for humans? a) disruptors of cell membrane structure b) inhibitors of cell wall synthesis Oc) inhibitors of protein synthesis d) antimetabolites RESET e) inhibitors of DNA synthesis Cancel DoneMany antibiotics used in modern medicine are compounds made by fungi that inhibit bacterial protein synthesis. Describe the specific effect of the following antimicrobial drugs: (i) Chloramphenicol (ii) Rifamycin
- There are fewer antifungal, anti protozoal, and antihelminth drugs compared to antibacterial drugs because these organism: a) do not cause many human infectious b) are not affected by antimicrobial drugs c) are so similar to human cells that drug selective toxicity is difficult d) are parasites found inside human cells e) have fewer target sites compared to bacteriaWhich antiretroviral drug class does Zidovudine (AZT) belong to? a) Non-nucleoside reverse transcriptase inhibitors (NNRTIs) b) Nucleoside reverse transcriptase inhibitors (NRTIs) c) Protease inhibitors d) Integrase inhibitorsFor each of the following antibiotics, give the spectrum, primary effect and briefly explain the mechanism of action: 1) Penicillins 2) Po1yrrryxin B 3) Vancomycin 4) Tetracyclins
- Which statement among A-D is false regarding bacterial toxins? A) O Hemolysıns are cell membrane disrupters that can rupture red blood cells. B) O Second mesengar pathway disrupters like cholera toxin produces a debilitating respiratory condition of the lungs. C) O Shiga toxin, tetanus toxin, and hemolysins are all types of exotoxins. D) O Superantigens elicit a hyperactive response by the immune system and can lead to shock. E) O None are false, A-D are all true statements.Why do the penicillin and cephalosporin groups of drugs have mildertoxicity than other antibiotics? What are their primary side effects?24) An opportunistic infection is a concern with which of the following medications? A) Antifungals B) Antiprotozoals C) Antibiotics D) All of the above
- Describe: a.) the mechanism of action of PF-07321332, the active compound found in the antiviral drug Paxlovid; b.) the viral target that it inhibits; and c.) the product formed. Use schemes where appropriate to support your answer. H H" H NH NH PF-07321332 FWhich of the following is true of selective toxicity? O 1) It refers to the process of determining the correct dose of a particular drug O 2) To be effective, an antimicrobial agent must be more toxic to the patient than 2) the pathogen O 3) It contributes to antibiotic resistance O 4) It refers to the body's ability to protect the brain and eye 5) It takes advantage of metabolic and structural differences between host and pathogenThe antibiotic susceptibility testing results of Staphylococcus showed zones of inhibition (absence of growth on zones) around discs of Penicilin, Teracycline, chloramphenicol, this means that a) S. aueres is resistant to all these antibiotics. b) S. aueres is susceptible to all these antibiotics. c) susceptible to only a couple of them d) neither are the correct choices