4. You are interviewing for a job a Merck. As part of your interview, you've been asked to develop a synthetic route from starting material A to target molecule B. Part 1. Conduct a simplifying retrosynthetic analysis of B. What are the strategic bonds you must consider? Part II. Suggest a set of specific reactions and conditions to prepare B starting from A. Pay special attention to relative stereochemistry ? MeO H3C H,C starting material (A) target molecule (B)

4. You are interviewing for a job a Merck. As part of your interview, you've been asked to develop a synthetic route from starting material A to target molecule B. Part 1. Conduct a simplifying retrosynthetic analysis of B. What are the strategic bonds you must consider? Part II. Suggest a set of specific reactions and conditions to prepare B starting from A. Pay special attention to relative stereochemistry ? MeO H3C H,C starting material (A) target molecule (B)

Chemistry

10th Edition

ISBN:9781305957404

Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Chapter1: Chemical Foundations

Section: Chapter Questions

Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...

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[References] How would you synthesize the following compounds from butanenitrile using reagents from the table? Use letters from the table to list reagents in the order used (first at the left). Example: ab Reagents 1. NaOH / H2O 2. H3O* SOCI2 1. NABH4 a e i 2. H3O* 1. ВНз / THF 2. НаО2/ NaOН b f 1. LIAIH4 1. CH3CH2MGBR / dry ether 2. H30* j 2. H3O* 1. (CH3)2CHMGB / dry ether 2. H30* PBR3 g NaCN k d Dess-Martin h CrO3 / H30* conc. HCI periodinane in CH2CI2 a) 2-Methyl-3-hexanone b) Pentanoic acid
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Select reagents from the following table to bring about this conversion. a. HOCH₂ CH₂ OH, H+ 1. Os04 2. NaHSO3 RCO3 H H3O+ NaBH₁ b. (Enter your result as a string of letters, in the order that you wish to use the reagents, i.e. ade.) C. d. e. LOH f. g. HO dihydropyran, H+ 1. BH3 2. NaOH, H₂O, H2₂ O2 OH
3. Provide the product of the haloform reaction shown below, as well as a mechanism for its formation. 1. Br2, NaOH 2. H3O+
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What is a mechanistic step for this reaction? Click on a letter A through D to answer. fuming H2SO4 SO3H он A. c. В. D.
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