4) Propanoic acid is a carboxylic acid. List four other propionic acid derivatives, and rank them in order of their expected reactivity toward nucleophilic acyl substitution. [self-study not grade: Which one is most likely used in Friedel-Crafts acylation? Which one is most likely used in alkylation reaction involving base (to deprotonate a-hydrogen) and alkyl halide? Why? What would an amide be synthetically useful for? ]

4) Propanoic acid is a carboxylic acid. List four other propionic acid derivatives, and rank them in order of their expected reactivity toward nucleophilic acyl substitution. [self-study not grade: Which one is most likely used in Friedel-Crafts acylation? Which one is most likely used in alkylation reaction involving base (to deprotonate a-hydrogen) and alkyl halide? Why? What would an amide be synthetically useful for? ]

Chemistry

10th Edition

ISBN:9781305957404

Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Chapter1: Chemical Foundations

Section: Chapter Questions

Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...

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Question

4) Propanoic acid is a carboxylic acid. List four other propionic acid derivatives, and rank them
in order of their expected reactivity toward nucleophilic acyl substitution.
[self-study not grade: Which one is most likely used in Friedel-Crafts acylation? Which one is
most likely used in alkylation reaction involving base (to deprotonate a-hydrogen) and alkyl
halide? Why? What would an amide be synthetically useful for? ]

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Step 1: Nucleophilic acyl reaction

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Step 2: Propionic acid derivatives and their reactivity towards nucleophilic acyl substitution

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Step 3: Most likely used propionic acid derivative for Friedel-Crafts acylation

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Step 4: Most likely used propionic acid derivative for alkylation involving base

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Step 5: Synthetic uses of amide

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