Homework Help is Here – Start Your Trial Now!
Science
Biochemistry
3. You are studying an interaction between an antibody and the antigen shown below. The amine next to the benzene ring has a pKa of 10.5 and the carboxylic acid has a pKa of 4.2. Circle each of these functional groups on the molecule below. (b) NH₂ HO B. Draw the structure of the antigen at pH 7.4. pra Yantela sble OH V N 148 M3 المهم له (9) vionA EAM C. There is one ionic bond and 3 hydrogen bonds that occur between the antibody and antigen. The ionic bond forms between a glutamate on the antibody and the protonated amine of the antigen. One of the hydrogen bond forms between a serine side chain on the antibody and the carboxylic acid of the antigen. Draw the ionic bond, including the full chemical structure of the side chain of the antibody. Indicate the ionic bond with a wavy line. D. A mutation occurs in the antibody such that the serine described above changes to an alanine. Do you expect the antigen to bind more or less tightly in the mutant compared to the original? Briefly explain.

3. You are studying an interaction between an antibody and the antigen shown below. The amine next to the benzene ring has a pKa of 10.5 and the carboxylic acid has a pKa of 4.2. Circle each of these functional groups on the molecule below. (b) NH₂ HO B. Draw the structure of the antigen at pH 7.4. pra Yantela sble OH V N 148 M3 المهم له (9) vionA EAM C. There is one ionic bond and 3 hydrogen bonds that occur between the antibody and antigen. The ionic bond forms between a glutamate on the antibody and the protonated amine of the antigen. One of the hydrogen bond forms between a serine side chain on the antibody and the carboxylic acid of the antigen. Draw the ionic bond, including the full chemical structure of the side chain of the antibody. Indicate the ionic bond with a wavy line. D. A mutation occurs in the antibody such that the serine described above changes to an alanine. Do you expect the antigen to bind more or less tightly in the mutant compared to the original? Briefly explain.

Biochemistry
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
See similar textbooks
icon
Related questions
Question
3. You are studying an interaction between an antibody and the antigen shown below. The amine next to the benzene ring has a pKa of 10.5 and the carboxylic acid has a pKa of 4.2. Circle each of these functional groups on the molecule below. (b) Y NH₂ HO B. Draw the structure of the antigen at pH 7.4. Santeita oble OHM- pra 120773 1111 Suish MS HJ HO ng bbsonings sd (3) ~ misn 11 ال مام له Nor Tesn prifto emen (JurisionA WAS Wa Judas C. There is one ionic bond and 3 hydrogen bonds that occur between the antibody and antigen. The ionic bond forms between a glutamate on the antibody and the protonated amine of the antigen. One of the hydrogen bond forms between a serine side chain on the antibody and the carboxylic acid of the antigen. Draw the ionic bond, including the full chemical structure of the side chain of the antibody. Indicate the ionic bond with a wavy line. D. A mutation occurs in the antibody such that the serine described above changes to an alanine. Do you expect the antigen to bind more or less tightly in the mutant compared to the original? Briefly explain.
Transcribed Image Text:3. You are studying an interaction between an antibody and the antigen shown below. The amine next to the benzene ring has a pKa of 10.5 and the carboxylic acid has a pKa of 4.2. Circle each of these functional groups on the molecule below. (b) Y NH₂ HO B. Draw the structure of the antigen at pH 7.4. Santeita oble OHM- pra 120773 1111 Suish MS HJ HO ng bbsonings sd (3) ~ misn 11 ال مام له Nor Tesn prifto emen (JurisionA WAS Wa Judas C. There is one ionic bond and 3 hydrogen bonds that occur between the antibody and antigen. The ionic bond forms between a glutamate on the antibody and the protonated amine of the antigen. One of the hydrogen bond forms between a serine side chain on the antibody and the carboxylic acid of the antigen. Draw the ionic bond, including the full chemical structure of the side chain of the antibody. Indicate the ionic bond with a wavy line. D. A mutation occurs in the antibody such that the serine described above changes to an alanine. Do you expect the antigen to bind more or less tightly in the mutant compared to the original? Briefly explain.
Expert Solution
steps

Step by step

Solved in 4 steps with 6 images

SEE SOLUTIONCheck out a sample Q&A here
Blurred answer
Recommended textbooks for you
Biochemistry
Biochemistry
Biochemistry
ISBN:
9781319114671
Author:
Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:
W. H. Freeman
Lehninger Principles of Biochemistry
Lehninger Principles of Biochemistry
Biochemistry
ISBN:
9781464126116
Author:
David L. Nelson, Michael M. Cox
Publisher:
W. H. Freeman
Fundamentals of Biochemistry: Life at the Molecul…
Fundamentals of Biochemistry: Life at the Molecul…
Biochemistry
ISBN:
9781118918401
Author:
Donald Voet, Judith G. Voet, Charlotte W. Pratt
Publisher:
WILEY
Biochemistry
Biochemistry
Biochemistry
ISBN:
9781305961135
Author:
Mary K. Campbell, Shawn O. Farrell, Owen M. McDougal
Publisher:
Cengage Learning
Biochemistry
Biochemistry
Biochemistry
ISBN:
9781305577206
Author:
Reginald H. Garrett, Charles M. Grisham
Publisher:
Cengage Learning
Fundamentals of General, Organic, and Biological …
Fundamentals of General, Organic, and Biological …
Biochemistry
ISBN:
9780134015187
Author:
John E. McMurry, David S. Ballantine, Carl A. Hoeger, Virginia E. Peterson
Publisher:
PEARSON
SEE MORE TEXTBOOKS