3. Amino acid residues and peptide bonds (a) Draw the chemical structure of F, S and H joined by peptide bonds and also connected to neighboring residues as found in a protein. (b) Include all charges as expected at physiological pH (pH = = 7.5) (c) Rank these three amino acid residues by hydrophobicity, pKa, and by nucleophilicity (d) For the central amino acid residue, identify the phi and psi dihedral angles by drawing a curved arrow indicating rotation about the chemical bond. (e) What group(s) eclipse each other if Phi = 0 degrees? Words and Pictures. (f) While Phi = 0 is not well tolerated, Psi = 0 is not uncommon, a so-called "allowed" but not most-favored region of the Ramachandran plot. What group(s) eclipse each other if Psi = 0 degrees and why is this less problematic than the situation created by Phi = 0. Words and Pictures

Biochemistry
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ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
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Chapter1: Biochemistry: An Evolving Science
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3. Amino acid residues and peptide bonds
(a) Draw the chemical structure of F, S and H joined by peptide bonds and also
connected to neighboring residues as found in a protein.
(b) Include all charges as expected at physiological pH (pH = 7.5)
(c) Rank these three amino acid residues by hydrophobicity, pKa, and by nucleophilicity
(d) For the central amino acid residue, identify the phi and psi dihedral angles by drawing
a curved arrow indicating rotation about the chemical bond.
(e) What group(s) eclipse each other if Phi = 0 degrees? Words and Pictures.
(f) While Phi = 0 is not well tolerated, Psi = 0 is not uncommon, a so-called "allowed"
but not most-favored region of the Ramachandran plot. What group(s) eclipse each
other if Psi = 0 degrees and why is this less problematic than the situation created by
Phi = 0. Words and Pictures
Transcribed Image Text:3. Amino acid residues and peptide bonds (a) Draw the chemical structure of F, S and H joined by peptide bonds and also connected to neighboring residues as found in a protein. (b) Include all charges as expected at physiological pH (pH = 7.5) (c) Rank these three amino acid residues by hydrophobicity, pKa, and by nucleophilicity (d) For the central amino acid residue, identify the phi and psi dihedral angles by drawing a curved arrow indicating rotation about the chemical bond. (e) What group(s) eclipse each other if Phi = 0 degrees? Words and Pictures. (f) While Phi = 0 is not well tolerated, Psi = 0 is not uncommon, a so-called "allowed" but not most-favored region of the Ramachandran plot. What group(s) eclipse each other if Psi = 0 degrees and why is this less problematic than the situation created by Phi = 0. Words and Pictures
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