5. The amino acid sequences of three peptide fragments are shown below.Peptide 1:QAMGRAGDLKYLGLHSVPeptide 2: ALMALFMVMALVLVSVLFIAPeptide 3: MVEDLLKQIARYLISE(a) Circle all of the charged residues in peptide 1 (assume pH = 7.0). Box all of the aromatic residuesin peptide 2. Underline all of the nonpolar residues in peptide 3.(b) Determine the net charge of the predominant form of each of the peptides at pH 4.5 and pH 11.5.Assume the ionizable groups have the pKa values listed in Table 2.1 of your text.(c) Which of these peptides would be most likely to be found as an a helix in a soluble (cytoplasmic)protein? Which would be most likely to be found as an a helix in a transmembrane protein? Whichwould be least likely to form an a helix of any kind? Briefly explain your answers.

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Answered: 5. The amino acid sequences of three…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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2. Estimate the pl of a Peptide. Estimate the pl for the following peptide: EHSLRGGA 3. Estimate the pl of a Peptide. Estimate the pl for the following peptide: GKAHHWEA
6. b. Draw a box around the disulfide bridge in oxytocin, if present, or write "none". 7. Mark each peptide bond in oxytocin by making the corresponding line in the structure thicker or marking it with a different color. The first one is shown for you as an example (in dark orange). 8. Number the central carbon of each amino acid in oxytocin by pointing a small arrow to it or by circling the corresponding vertex in the image. Numbers 1 and 2 indicate the central carbons of the first and second amino acids of oxytocin, and are shown for you as an example. 9. Fill out the following table, listing amino acids that make up oxytocin in order, from the N terminus to the C terminus, characterizing each amino acid by the properties of its R group (side chains), and briefly indicating the reasoning for the characterization. You may consult amino acid groupings by category in the slides (or the textbook, p.49), but you must explain the reasoning for each in your own words. CO 1 AA# Abbre- Full…
Consider the peptide HRDMQSGAI. Part: 0/5 Part 1 of 5 Identify the side chains of the amino acid residues in the peptide that are nonpolar. Check all that apply. H R D ☐ M 1Q S G None of the above x
For each amino acid, show the structure, 1-letter abbreviation, 3-letter abbreviation, class (non-polar, polar, positive or negative), special props, side chain pKa)
5. Refer to Model 2 for information relevant to this question. A sample of the peptide Lys-Glu-Ser has a net charge of zero between what two pH values? What is the pl of Lys-Glu-Ser? Model 2: The pl of a peptide is determined by examining the ionizable groups. The protonated and unprotonated forms of each ionizable group are in equilibrium. Consider the peptide Lys-Glu-Ser shown below at pH 7.2. The complete structure is on on the left and a stylized structure with just the ionizable groups is on the right. While the N-terminal is depicted as protonated, a sample of Lys-Glu-Ser is composed of a population of molecules and within that population some molecules contain a non-protonated N-terminal group at pH 7.2. may H3N* COO- H3N-CH-CIN-CH C N-CH C- H. pK 3.5 OH H. pK= 8.5 COO- CH2 CH2 CH2 NH, pK 10.0 pK 4.2 CH2 CH2 OH CH2 c=0
What charge is carried by the peptide FREEENERGY at pH 7? (pKas: N-terminus: 9; C-terminus: 3; Arginine 11.6; Glutamic acid, 4.3)
please match all of them
None
1 Draw the following polypeptide: Met- Tyr-Val-Ser-Asn 2A Draw the hydrolysis of a dipeptide consisting of phenylaline and glutamic acid. 2B What are the fuctional group present in the side chains of the amino acids.( phenylalanine and glutamic acid) 2C are the sidechains in part 2B hydrophobic or polar 2D where would you expect to find them ( surface or interior of a protein) ? why ?
What is the PRIMARY STRUCTURE (amino acid sequence) of the peptide depicted below? NOTE - PROVIDE YOUR ANSWER USING SINGLE LETTER AMINO ACID CODES, without spaces between each letter. HO. OH OH -NH ОНО но. OH OH NH ENH но NH2
6) Circle one amino acid in this peptide (hint: draw lines between not through atoms). Kahalalide F NH HN HO NH HN HN

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