2. Propose starting materials and reagents to achieve the following synthesis. Assume the circled region was added as the electrophile. (Hint, there will be a decarboxylation.) ẞ-ketoester OH
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- I need help please1) How would you prepare phenylacetic acid (PhCH2CO2H) from benzyl bromide (PHCH2B1)?2a. Use the malonic ester synthesis to synthesize the following carboxylic acid. Show all necessary reagents and conditions and number them sequentially. You do not need to show mechanistic steps. O O O₂N OH
- The widely used anticoagulant warfarin (see "Chemical Connections: From Moldy Clover to a Blood Thinner" in Chapter 18) is synthesized from 4-hydroxycoumarin, benzaldehyde, and acetone as shown in this retrosynthesis. Show how warfarin is synthesized from these reagents. OH OH Acetone + Warfarin 4Нydroxy- (a synthetic anticoagulant; racemic) coumarin BenzaldehydePlease help me with this question. Thank you.4. Propose an efficient synthetic route (along with intermediates) for the following transformation. Note: Use cyclohexane as the starting point for both cyclohexyl rings in the product.
- Use the reaction given below to answer the following questions. A CH₂OH B H₂O+ C + CH3NH3* D a) What are the approximate pKas of compounds A and B? b) The reaction given above is irreversible. Give a detailed explanation of the reaction and reaction mechanism. Your explanation should indicate your knowledge of the reactivity of carboxylic acid derivatives.Do3. Propose reagents for the following synthesis. Hint: It involves a decarboxylation. Etoi OEt