2. Null mutations are valuable genetic resources becausethey allow a researcher to determine what happens to anorganism in the complete absence of a particular protein. However, it is often not a trivial matter to determinewhether a mutation represents the null state of the gene.a. Geneticists sometimes use the following test forthe nullness of an allele in a diploid organism: If theabnormal phenotype seen in a homozygote for theallele is identical to that seen in a heterozygote(where one chromosome carries the allele in question and the homologous chromosome is known tobe completely deleted for the gene) then the alleleis null. What is the underlying rationale for thistest? What limitations might there be in interpreting such a result?

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
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Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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2. Null mutations are valuable genetic resources because
they allow a researcher to determine what happens to an
organism in the complete absence of a particular protein. However, it is often not a trivial matter to determine
whether a mutation represents the null state of the gene.
a. Geneticists sometimes use the following test for
the nullness of an allele in a diploid organism: If the
abnormal phenotype seen in a homozygote for the
allele is identical to that seen in a heterozygote
(where one chromosome carries the allele in question and the homologous chromosome is known to
be completely deleted for the gene) then the allele
is null. What is the underlying rationale for this
test? What limitations might there be in interpreting such a result?

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