2) There are many forms of cancer, all of which involve abnormal cell growth. The growth andproduction of cells, called cell proliferation, is known to involve an enzyme called proteinfarnesyltransferase (PFTase). It is thought that inhibitors pf PFTase may be useful as anticancerdrugs. The following molecule showed moderate activity as a potential PFTase inhibitor. Draw allstereoisomers of this compound.HOOH

Answered: Image /qna-images/answer/df01208c-2f41-484b-a281-fa0de4608d4d.jpg

Answered: 2) There are many forms of cancer, all…

Organic Chemistry

9th Edition

ISBN:9781305080485

Author:John E. McMurry

Publisher:John E. McMurry

Chapter26: Biomolecules: Amino Acids, Peptides, And Proteins

Section26.SE: Something Extra

Problem 53AP

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3a. 3b. 3c 3d. 3e. CO₂ clavulanic acid CH₂-OH H Answer the following questions about clavulanic acid. Does clavulanic acid inhibit D-alanyl-D-alanine transpeptidase? Does clavulanic acid contain a ß-lactam? Does clavulanic acid contain a thiazolium ring? What is the result of the treatment of penicillinase with clavulanic acid? Does clavulanic acid form a covalent acyl-enzyme intermediate with penicillinase?
An acid–base reaction of (R)-sec-butylamine with a racemic mixture of 2phenylpropanoic acid forms two products having different melting points and somewhat different solubilities. Draw the structure of these two products. Assign R and S to any stereogenic centers in the products. How are the two products related? Choose from enantiomers, diastereomers, constitutional isomers, or not isomers of each other.
Determining if a Base Is Strong Enough to Deprotonate an Acid Which of the following bases is strong enough to deprotonate N,Ndimethylacetamide [CH3CON(CH3)2, pKa = 30], so that equilibrium favors the products:(a)NaNH2; (b) NaOH?
Your answer is incorrect. NH2 O (15,3S)-3-isopropylcyclohexanamine O (1R,3R)-3-isopropylcyclohexanamine (1R,3S)-3-isopropylcyclohexanamine ○ (15,3R)-3-isopropylcyclohexanamine = SUPPOR
H NH3 H₂N CO₂ Lysine CO₂ a-ketoglutarate NADPH/H* H H NH3* NADPH CO₂ Saccharopine The first step in the biological degradation of lysine is reductive amination with a-ketoglutarate to give saccharopine. Nicotinamide adenine dinucleotide phosphate (NADPH), a relative of NADH, is the reducing agent. Draw curved arrows to show the movement of electrons in this step of the reaction mechanism. Arrow-pushing Instructions H₂N H NH3+ CO₂ H-A CO₂ OH *H3N H :A CO₂ جائے
Following is a retrosynthesis for the coronary vasodilator ganglefene. (a) Propose a synthesis for ganglefene from 4-hydroxybenzoic acid and 3-methyl-3-buten-2-one. (b) Is ganglefene chiral? If so, which of the possible stereoisomers are formed in this synthesis?
Draw the structure of the following three isomeric amides with chemical formula C,H NO. Amide #1: N-ethylcyclopropanecarboxamide Amide #2: (Z)-3-hexenamide Amide #3: N-methylcyclobutanecarboxamide • Consider E/Z stereochemistry of alkenes. • Draw one structure per sketcher. Add additional sketchers using the drop-down menu in the bottom right corner. • Separate structures with + signs from the drop-down menu. opy aste ChemDoodle (Provious Next Email Instructor Save a
Draw the following compounds. a) (25,5Z)-2-amino-6-bromohept-5-enoic acid b) (S)-2,3-epoxy-4-hydroxycyclohexanone
Paroxetine (Paxil) is an antidepressant that is a member of a family of drugs known as Selective Serotonin Reuptake Inhibitors (SSRIS). This family of drugs also includes fluoxetine (Prozac) and sertraline (Zoloft). SSRIS work by inhibiting the reuptake of the neurotransmitter serotonin in the synapses of the central nervous system follow- ing release of serotonin during excitation of individual nerve cells. Between firings, the serotonin is taken back up by a nerve cell in preparation for firing again. Inhibition of reuptake has the effect of increasing the time serotonin molecules remain in the syn- apses following excitation, leading to a therapeutic effect. In one synthesis of parox- etine, the following reagents are used. Draw the structures of synthetic intermediates A and B. F НО SOCI, A B HO Pyridine
Given this retrosynthetic analysis, propose a synthesis for the antihistamine p-methyldiphenhydramine. Is p-methyldiphenhydramine chiral? If so, how many of the possible stereoisomers are formed in this synthesis? H NMe, НО Br p-Methyldiphenhydramine +
H₂N NH NH₂ COOH Arginine O A, B- heterocyclic aromatic amines, C - 1° aliphatic amine OA - 1º aliphatic amine, B - 2º aliphatic amine, C - 1° aliphatic amine A - 2º aromatic amine, B - heterocyclic aromatic amine, C - 3° aliphatic amine A - 3º aromatic amine, B - heterocyclic aromatic amine, C - 1° aliphatic amine O A - 3º aliphatic amine, B - heterocyclic aromatic amine, C - 1° aliphatic amine
The following three derivatives of succinimide are anticonvulsants that have found use in the treatment of epilepsy, particularly petit mal seizures. Q. Propose experimental conditions for the conversion of (C) to (D).

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