2) There are many forms of cancer, all of which involve abnormal cell growth. The growth andproduction of cells, called cell proliferation, is known to involve an enzyme called proteinfarnesyltransferase (PFTase). It is thought that inhibitors pf PFTase may be useful as anticancerdrugs. The following molecule showed moderate activity as a potential PFTase inhibitor. Draw allstereoisomers of this compound.HOOH

Answered: Image /qna-images/answer/df01208c-2f41-484b-a281-fa0de4608d4d.jpg

Answered: 2) There are many forms of cancer, all…

Organic Chemistry

9th Edition

ISBN:9781305080485

Author:John E. McMurry

Publisher:John E. McMurry

Chapter26: Biomolecules: Amino Acids, Peptides, And Proteins

Section26.SE: Something Extra

Problem 53AP

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The following three derivatives of succinimide are anticonvulsants and have found use in the treatment of epilepsy, particularly petit mal seizures. Ph Ph `N' `N' ČH3 ČH3 Methsuximide Ethosuximide Phensuximide Following is a synthesis of phensuximide. CN Ph CN Ph CN 1. NaOH, H2O 2. HC, Н20 NaOEt KCN Ph-CHO cOOEt H cOOEt NC COOEt 3. Нeat Ethyl cyanoacetate (A) (B) Benzaldehyde Ph Ph Ph CH;NH2 НООС СООН Et0oC COOEt `N' (C) (D) ČH3 Phensuximide Methsuximide is formed by a similar pathway to that shown for phensuximide. Draw the structure of the compound that reacts with ethyl cyanoacetate in the synthesis of methsuximide.
An acid–base reaction of (R)-sec-butylamine with a racemic mixture of 2phenylpropanoic acid forms two products having different melting points and somewhat different solubilities. Draw the structure of these two products. Assign R and S to any stereogenic centers in the products. How are the two products related? Choose from enantiomers, diastereomers, constitutional isomers, or not isomers of each other.
Classify each amine as a primary, secondary, or tertiary.
Your answer is incorrect. NH2 O (15,3S)-3-isopropylcyclohexanamine O (1R,3R)-3-isopropylcyclohexanamine (1R,3S)-3-isopropylcyclohexanamine ○ (15,3R)-3-isopropylcyclohexanamine = SUPPOR
Which of these compounds would not show up on a TLC plate under a UV lamp? ○ All of these compounds will show up under UV. ○ 2-bromoacetanilide Phenylacetic acid O 2-Chlorobenzoic acid ○ Propyl 4-hydroxybenzoate
H NH3 H₂N CO₂ Lysine CO₂ a-ketoglutarate NADPH/H* H H NH3* NADPH CO₂ Saccharopine The first step in the biological degradation of lysine is reductive amination with a-ketoglutarate to give saccharopine. Nicotinamide adenine dinucleotide phosphate (NADPH), a relative of NADH, is the reducing agent. Draw curved arrows to show the movement of electrons in this step of the reaction mechanism. Arrow-pushing Instructions H₂N H NH3+ CO₂ H-A CO₂ OH *H3N H :A CO₂ جائے
Following is a retrosynthesis for the coronary vasodilator ganglefene. (a) Propose a synthesis for ganglefene from 4-hydroxybenzoic acid and 3-methyl-3-buten-2-one. (b) Is ganglefene chiral? If so, which of the possible stereoisomers are formed in this synthesis?
Identify the product CHICHINH, CH CH₂ CH2CH3 ON-Ethylpropanamide + propanoic acid ON,N-Diethylpropanamide + propanoic acid ON-Ethylethanamide + ethanoic acid ON,N-Diethylethanamide + ethanoic acid
What is the right answer?
Draw the following compounds. a) (25,5Z)-2-amino-6-bromohept-5-enoic acid b) (S)-2,3-epoxy-4-hydroxycyclohexanone
Paroxetine (Paxil) is an antidepressant that is a member of a family of drugs known as Selective Serotonin Reuptake Inhibitors (SSRIS). This family of drugs also includes fluoxetine (Prozac) and sertraline (Zoloft). SSRIS work by inhibiting the reuptake of the neurotransmitter serotonin in the synapses of the central nervous system follow- ing release of serotonin during excitation of individual nerve cells. Between firings, the serotonin is taken back up by a nerve cell in preparation for firing again. Inhibition of reuptake has the effect of increasing the time serotonin molecules remain in the syn- apses following excitation, leading to a therapeutic effect. In one synthesis of parox- etine, the following reagents are used. Draw the structures of synthetic intermediates A and B. F НО SOCI, A B HO Pyridine
Given this retrosynthetic analysis, propose a synthesis for the antihistamine p-methyldiphenhydramine. Is p-methyldiphenhydramine chiral? If so, how many of the possible stereoisomers are formed in this synthesis? H NMe, НО Br p-Methyldiphenhydramine +

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