2 ENTROPYprotein lysozyme unfolds at a transition temperature of 75.5°C, with a standard enthalpy oftransition of 509.0 kJ mol-1.(a)What is the entropy of unfolding of lysozyme at 75.5°C?(b) Knowing that the constant-pressure heat capacity of lysozyme is 6.28 kJ K³ mol greater inits unfolded state than in its folded state, what is the entropy of unfolding at 25.0°C?Hints: (a) Folding and unfolding can be described by an expression for a reversible phase tran-folded and unfolded state, respectively) such that they include the difference in heat capacitiessition (e.g. solid-liquid). (b) Rewrite the expressions for the two terms including cp data (forfor which you can then use 6.28 kJ K³ mot!.

B) Entropy of unfolding at 25°C:To find the entropy change at 25°C, we need to consider the change…

Answered: 2 ENTROPY protein lysozyme unfolds at a…

Chemistry: Principles and Reactions

8th Edition

ISBN:9781305079373

Author:William L. Masterton, Cecile N. Hurley

Publisher:William L. Masterton, Cecile N. Hurley

Chapter16: Spontaneity Of Reaction

Section: Chapter Questions

Problem 78QAP

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3. A particular protein heat denatures with a melting temperature Tm = 332 K with an enthalpy of unfolding, AHm = 372 kJmol-¹. (a) What is the entropy of unfolding in kJ mol-1 K-1 at Tm? (b) If ACp is 6.6 kJ mol-1 K-1, at what temperature does the free energy of unfolding (AG unfolding) have the greatest value (i.e. the native state is most stable)? (c) Calculate the value of AG and K at this temperature.
The density of rhombic sulfur is 2.070 g cm-3 with a standard molar entropy of 31.80 J K-1 mol-1. The density of monoclinic sulfur is 1.957 g cm-3 with a standard molar entropy of 32.6 J K-1 mol-1. (a) Can an increase in temperature be expected to make monoclinic sulfur more stable than rhombic sulfur? (b) If so, at what temperature will the transition occur at 1 bar?
At 298K, the enthalpy of denaturation of hen egg white lysozyme is +217.6 kJ/mol, and the changein the constant pressure molar heat capacity resulting from denaturing this protein is +6.3 kJ/molK. Estimate the enthalpy of denaturation of this protein at 351 K (the melting temperature of hen egg white lysozyme at atmospheric pressure). (ans = +552 kJ/mol)
Wheeler and Mathews (J. Biol. Chem. 287:31218–31222 (2012)) reportedthe NAD+ and NADH concentrations in yeast mitochondria as 20 mM and0.3 mM, respectively. Consider the malate dehydrogenase reaction, which is part of the citric acid cycle:malate + NAD+ → oxaloacetate + NADH + H+ ΔG∘' = +29.7 kJ/molIf malate concentration in yeast mitochondria is 0.4 mM, what is the maximum concentration of oxaloacetate needed to make the reaction exergonic at pH 7.0 and 37°C?
the molar at 298 K. E3B.3(b) Estimate the change in the molar entropy of N₂(g) when the temperature is lowered from 298 K to 273 K, given that Cp,m(N₂) = 29.125 J K¯'mol¹ at 298 K. E3B.4(a) The molar entropy of a sample of neon at 298 K is 146.22 J K¹ mol™˜¹. 500 IZ
Calculate the standard reaction entropy at 298 K of (a) 2 CH3CHO(g) + O2(g) → 2 CH3COOH(I)(b) 2 AgCI(s) + Br2(l) → 2 AgBr(s) + Cl2(g)(c) Hg(l) + Cl2(g) → HgCI2(s)(d) Zn(s) + Cu2+(aq) → Zn2+(aq) + Cu(s)(e) C12H22O11(s) + 12 O2(g) → 12 CO2(g) + 11 H2O(l)
(d) If the mass of the metal is 196 grams, what is its specific heat capacity?(e) What is the change of water’s entropy? Note the volume of water stays the same.(f) What is the change of total entropy of the system, including both water and metal?
The temperature dependence of the heat capacity of non-metallic solids is found to follow the Debye T3 -law at very low temperatures, with Cp,m = aT3. (a) Derive an expression for the change in molar entropy on heating for such a solid. (b) For solid nitrogen, a= 6.15 x 10-3 J K-4 mol-1. What is the molar entropy of solid nitrogen at 5 K?
3B.8 What is the change in entropy when (a) 100 g of ice is melted at 0 °C, (b) 100 g of water is heated from 0 °C to 100 °C, and (c) 100 g of water is vaporized at 100 °C? Use the values for each step to calculate the change in entropy when 100 g of ice is converted into water vapour at 100 °C. Suppose that the changes are brought about by a heater that supplies energy at a constant rate. Sketch a graph showing (a) the change in temperature of the system, (b) the enthalpy of the system, (c) the entropy of the system as a function of time.
The value of ASn for the catalytic hydrogenation of acetylene to ethene, C2H2(g) + H2(9) CH4(9). is J/K.
in a particular solution at 30 degrees celcius the ratio of beta-d-glucose to linear glucose is 320:1. Calculate gibbs free energy at standard state for conversion of linear to beta-d-glucose. (R=8.3145 J mol-1 K-1)
Calculate the standard reaction entropy at 298 K of (a) 2CH3CHO(g) + O2→2CH3COOH(1) (b) 2AgCl(s) + Br₂(1) → 2AgBr(s) +Cl₂(g) (c) Hg(1) + Cl₂(g) → HgCl₂(s)

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