In both examples below the reactants shown are combined to bring about a nucleophilic substitution (SN1, SN2) and/or elimination (E1, E2) reaction. What is the major reaction that takes place in each case? CH3 CH3 NaOCH2CH3 CH3CH2OH Br Br KOH CH3CH2OH
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- In both examples below the reactants shown are combined to bring about a nucleophilic substitution (SN1, SN2) and/or elimination (E1, E2) reaction. What is the major reaction that takes place in each case? -Br CH3 CH3CH₂CCH3 ci Nal acetone NaOCH₂CH3 CH3CH₂OH SN2 SN2In both examples below the reactants shown are combined to bring about a nucleophilic substitution (SN1, Sn2) and/or elimination (E1, E2) reaction. What is the major reaction that takes place in each case? CH3 NaOCH2CH3 CH,CH,CCH3 CH;CH,OH SN2 E2 mixture of SN1 and E1 NaSCH3 CH3OH CH2IIn both examples below the reactants shown are combined to bring about a nucleophilic substitution (S1, Sy2) and'or elimination (EI, E2) reaction What is the major reaction that takes place in each case? CH, CH, CH,CH,CHCCH, H20 Br NaNg CH,OH CH,CH,CHCH,CH, SN2
- Pleas explain how this process occurs. Identify SN1, SN2, E2, E1, nucleophiles and electrophiles.In both examples below the reactants shown are combined to bring about a nucleophilic substitution (SN1, SN2) and/or elimination (E1, E2) reaction. What is the major reaction that takes place in each case?In both examples below the reactants shown are combined to bring about a nucleophilic substitution (SN1, SN2) and/or elimination (E1, E2) reaction. What is the major reaction that takes place in each case?
- Which of the following nucleophilic substitution reactions will take place?3. SN2 reactions are useful in the synthesis of many pharmaceutical compounds. The antiviral agent acyclovir can be prepared using an S№2 reaction as shown below followed by a hydrolysis reaction. The hydrolysis reaction will be discussed in CHEM 40B. R'RN A + B SN2 R'RN ELECTROPHILE: من مهمه NUCLEOPHILE: Identify which molecule (A or B) would serve as the electrophile and which would serve as the nucleophile in the S№2 reaction. Place your responses in the box below. Connections to biology The amino acid cysteine is one of the common building blocks of proteins that contains the thiol (SH) functional group. The reactivity of the thiol group allows researchers to connect various molecules to proteins, a process known as labeling. For example, it is possible to connect fluorescent probes that allow us to trace the fate of proteins in the cell. H SH O Cysteine amino acid within a protein chain sa acyclovir LG H₂N S OH H O Cysteine amino acid labeled with electrophilic probe…6. The following reaction is an example of OH A) SN1 B) SN2 Br NaOH EtOH C) E1 D) E2 7. In the above reaction (Q6), what is the role of NaOH? A) It acts as an acid and reacts with EtOH B) It acts as nucleophile and attacks on electrophilic carbon in bromoprop C) It acts as a base and reacts with phenolic OH and forms phenolate ion D) It acts as a spectator
- Substitution reaction4. A CHEM 245 student wants to synthesize some ethylene glycol to use as antifreeze in his radiator this winter. He proposes the following reaction to his instructor, who quickly explains that this reaction won't work as proposed due to the student's choice of reagent. 1) NaH 2) H20 OH Но a) Why can't sodium hydride (NaH) be used as the nucleophile in the reaction above? b) Propose an alternate reagent that COULD be used with the ethylene oxide to successfully give the desired ethylene glycol product.9) Suppose I want to perform a simple substitution reaction, replacing the OH with a Cl in the following compound. Which of the following reagents works best? Explain (and that means explain why the wrong answers are wrong as well as why the right answer is right). Option A: Addition of HBr Option B: Addition of SOC12/pyridine Option C: Addition of SOCl2 only OH ? J1