3. SN2 reactions are useful in the synthesis of many pharmaceutical compounds. The antiviral agent acyclovir can be prepared using an SN2 reaction as shown below followed by a hydrolysis reaction. The hydrolysis reaction will be discussed in CHEM 40B. SN2 . . - R'RN R'RN H₂N A B acyclovir Identify which molecule (A or B) would serve as the electrophile and which would serve as the nucleophile in the SN2 reaction. Place your responses in the box below. OH

Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
Section: Chapter Questions
Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
icon
Related questions
icon
Concept explainers
Question
3. SN2 reactions are useful in the synthesis of many pharmaceutical compounds. The antiviral agent
acyclovir can be prepared using an S№2 reaction as shown below followed by a hydrolysis reaction.
The hydrolysis reaction will be discussed in CHEM 40B.
R'RN
A
+
B
SN2
R'RN
ELECTROPHILE:
من مهمه
NUCLEOPHILE:
Identify which molecule (A or B) would serve as the electrophile and which would serve as the
nucleophile in the S№2 reaction. Place your responses in the box below.
Connections to biology
The amino acid cysteine is one of the
common building blocks of proteins that
contains the thiol (SH) functional group. The
reactivity of the thiol group allows
researchers to connect various molecules to
proteins, a process known as labeling. For
example, it is possible to connect
fluorescent probes that allow us to trace the fate of proteins in the cell.
H
SH
O
Cysteine amino acid
within a protein chain
sa
acyclovir
LG
H₂N
S
OH
H
O
Cysteine amino acid labeled
with electrophilic probe
lodoacetamides react efficiently with cysteine. In the following exercise (Q4-6), you will explore the reactivity of
iodoacetamides with some amino acid residues.
Transcribed Image Text:3. SN2 reactions are useful in the synthesis of many pharmaceutical compounds. The antiviral agent acyclovir can be prepared using an S№2 reaction as shown below followed by a hydrolysis reaction. The hydrolysis reaction will be discussed in CHEM 40B. R'RN A + B SN2 R'RN ELECTROPHILE: من مهمه NUCLEOPHILE: Identify which molecule (A or B) would serve as the electrophile and which would serve as the nucleophile in the S№2 reaction. Place your responses in the box below. Connections to biology The amino acid cysteine is one of the common building blocks of proteins that contains the thiol (SH) functional group. The reactivity of the thiol group allows researchers to connect various molecules to proteins, a process known as labeling. For example, it is possible to connect fluorescent probes that allow us to trace the fate of proteins in the cell. H SH O Cysteine amino acid within a protein chain sa acyclovir LG H₂N S OH H O Cysteine amino acid labeled with electrophilic probe lodoacetamides react efficiently with cysteine. In the following exercise (Q4-6), you will explore the reactivity of iodoacetamides with some amino acid residues.
Expert Solution
steps

Step by step

Solved in 3 steps with 3 images

Blurred answer
Knowledge Booster
Aromatic Compounds
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, chemistry and related others by exploring similar questions and additional content below.
Similar questions
Recommended textbooks for you
Chemistry
Chemistry
Chemistry
ISBN:
9781305957404
Author:
Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:
Cengage Learning
Chemistry
Chemistry
Chemistry
ISBN:
9781259911156
Author:
Raymond Chang Dr., Jason Overby Professor
Publisher:
McGraw-Hill Education
Principles of Instrumental Analysis
Principles of Instrumental Analysis
Chemistry
ISBN:
9781305577213
Author:
Douglas A. Skoog, F. James Holler, Stanley R. Crouch
Publisher:
Cengage Learning
Organic Chemistry
Organic Chemistry
Chemistry
ISBN:
9780078021558
Author:
Janice Gorzynski Smith Dr.
Publisher:
McGraw-Hill Education
Chemistry: Principles and Reactions
Chemistry: Principles and Reactions
Chemistry
ISBN:
9781305079373
Author:
William L. Masterton, Cecile N. Hurley
Publisher:
Cengage Learning
Elementary Principles of Chemical Processes, Bind…
Elementary Principles of Chemical Processes, Bind…
Chemistry
ISBN:
9781118431221
Author:
Richard M. Felder, Ronald W. Rousseau, Lisa G. Bullard
Publisher:
WILEY