3. SN2 reactions are useful in the synthesis of many pharmaceutical compounds. The antiviral agent acyclovir can be prepared using an SN2 reaction as shown below followed by a hydrolysis reaction. The hydrolysis reaction will be discussed in CHEM 40B. SN2 . . - R'RN R'RN H₂N A B acyclovir Identify which molecule (A or B) would serve as the electrophile and which would serve as the nucleophile in the SN2 reaction. Place your responses in the box below. OH
3. SN2 reactions are useful in the synthesis of many pharmaceutical compounds. The antiviral agent acyclovir can be prepared using an SN2 reaction as shown below followed by a hydrolysis reaction. The hydrolysis reaction will be discussed in CHEM 40B. SN2 . . - R'RN R'RN H₂N A B acyclovir Identify which molecule (A or B) would serve as the electrophile and which would serve as the nucleophile in the SN2 reaction. Place your responses in the box below. OH
Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
Section: Chapter Questions
Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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Transcribed Image Text:3. SN2 reactions are useful in the synthesis of many pharmaceutical compounds. The antiviral agent
acyclovir can be prepared using an S№2 reaction as shown below followed by a hydrolysis reaction.
The hydrolysis reaction will be discussed in CHEM 40B.
R'RN
A
+
B
SN2
R'RN
ELECTROPHILE:
من مهمه
NUCLEOPHILE:
Identify which molecule (A or B) would serve as the electrophile and which would serve as the
nucleophile in the S№2 reaction. Place your responses in the box below.
Connections to biology
The amino acid cysteine is one of the
common building blocks of proteins that
contains the thiol (SH) functional group. The
reactivity of the thiol group allows
researchers to connect various molecules to
proteins, a process known as labeling. For
example, it is possible to connect
fluorescent probes that allow us to trace the fate of proteins in the cell.
H
SH
O
Cysteine amino acid
within a protein chain
sa
acyclovir
LG
H₂N
S
OH
H
O
Cysteine amino acid labeled
with electrophilic probe
lodoacetamides react efficiently with cysteine. In the following exercise (Q4-6), you will explore the reactivity of
iodoacetamides with some amino acid residues.
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