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6. Procaine is a widely used local anesthetic. It has a short duration of action because it is rapidly hydrolyzed by esterases. Draw the products. H2N' 7. Ethacrynic acid is a diuretic that blocks 20-25% of sodium reabsorption, and is metabolized by GSTS. For the reaction below, circle the nucleophile, box the electrophile, and draw both the glutathione and cysteine conjugate. EXTRA CREDIT: Draw a mechanism (push arrows) for this reaction. + G-SH

6. Procaine is a widely used local anesthetic. It has a short duration of action because it is rapidly hydrolyzed by esterases. Draw the products. H2N' 7. Ethacrynic acid is a diuretic that blocks 20-25% of sodium reabsorption, and is metabolized by GSTS. For the reaction below, circle the nucleophile, box the electrophile, and draw both the glutathione and cysteine conjugate. EXTRA CREDIT: Draw a mechanism (push arrows) for this reaction. + G-SH

Chemistry
Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
Section: Chapter Questions
Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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**Question 6:** Procaine is a widely used local anesthetic. It has a short duration of action because it is rapidly hydrolyzed by esterases. Draw the products. Chemical structure of procaine: It includes an aromatic ring with an amino group (NH₂) attached to it, linked through an ester linkage to a tertiary amine. **Question 7:** Ethacrynic acid is a diuretic that blocks 20-25% of sodium reabsorption, and is metabolized by GSTs. For the reaction below, circle the nucleophile, box the electrophile, and draw both the glutathione and cysteine conjugate. Extra Credit: Draw a mechanism (push arrows) for this reaction. Chemical reaction: - **Ethacrynic Acid** structure: Aromatic ring with chlorine (Cl) substituents, a ketone (O=), and a carboxylic acid (OH). - **G-SH** (Glutathione): Shown as a thiol group ready to react. The reaction asks to identify the nucleophile and electrophile and to show the products of the glutathione and cysteine conjugation.
Transcribed Image Text:**Question 6:** Procaine is a widely used local anesthetic. It has a short duration of action because it is rapidly hydrolyzed by esterases. Draw the products. Chemical structure of procaine: It includes an aromatic ring with an amino group (NH₂) attached to it, linked through an ester linkage to a tertiary amine. **Question 7:** Ethacrynic acid is a diuretic that blocks 20-25% of sodium reabsorption, and is metabolized by GSTs. For the reaction below, circle the nucleophile, box the electrophile, and draw both the glutathione and cysteine conjugate. Extra Credit: Draw a mechanism (push arrows) for this reaction. Chemical reaction: - **Ethacrynic Acid** structure: Aromatic ring with chlorine (Cl) substituents, a ketone (O=), and a carboxylic acid (OH). - **G-SH** (Glutathione): Shown as a thiol group ready to react. The reaction asks to identify the nucleophile and electrophile and to show the products of the glutathione and cysteine conjugation.
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