1d regulation of the lack operon by the lack repressor is an example of negative regulation. what in general does it mean to say that a gene or operon is subject to negative regulation
Bacterial Genomics
The study of the morphological, physiological, and evolutionary aspects of the bacterial genome is referred to as bacterial genomics. This subdisciplinary field aids in understanding how genes are assembled into genomes. Further, bacterial or microbial genomics has helped researchers in understanding the pathogenicity of bacteria and other microbes.
Transformation Experiment in Bacteria
In the discovery of genetic material, the experiment conducted by Frederick Griffith on Streptococcus pneumonia proved to be a stepping stone.
Plasmids and Vectors
The DNA molecule that exists in a circular shape and is smaller in size which is capable of its replication is called Plasmids. In other words, it is called extra-chromosomal plasmid DNA. Vectors are the molecule which is capable of carrying genetic material which can be transferred into another cell and further carry out replication and expression. Plasmids can act as vectors.
1d regulation of the lack operon by the lack repressor is an example of negative regulation. what in general does it mean to say that a gene or operon is subject to negative regulation ?
E.coli bacterium intake glucose as a primary source of energy metabolism .
When a glucose is scarce , the E.coli bacterium induces the synthesis of several proteins for the utilization of lactose as an energy source .
lactose is disaccharide composed of glucose and galactose. the enzyme beta-galactosidase cleaves the bond between glucose and galactose ,whereas subsequent step convert galactose into glucose thereby yielding two molecules of glucose from single molecule of lactose.
Lac operon consist three enzyme :
- beta-galactosidase breakdown lactose
- lactose permease allows lactose to enter into the cell
- galactoside acetyl transferase acetylates no of proteins
All three gene transcribed by a single polycistronic mRNA from lac operon promoter called Plac
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