12.46 A three-generation pedigree for a particularhuman trait is shown in the following figure:Generation:I1 2II1 234III1 2 34 5a. What is the mechanism of inheritance for the trait?b. Which persons in the pedigree are known to be het-erozygous for the trait?c. What is the probability that III-2 is a carrier (het-erozygous)?d. If III-3 and III-4 marry, what is the probability thattheir first child will have the trait?

a.) Autosomal recessive because an affected child appeared even if none of the parents were…

Answered: 12.46 A three-generation pedigree for a…

Human Anatomy & Physiology (11th Edition)

11th Edition

ISBN:9780134580999

Author:Elaine N. Marieb, Katja N. Hoehn

Publisher:Elaine N. Marieb, Katja N. Hoehn

Chapter1: The Human Body: An Orientation

Section: Chapter Questions

Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...

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In the plant Arabidopsis, the loci for pod length (L, long;l, short) and fruit hairs (H, hairy; h, smooth) are linked16 m.u. apart on the same chromosome. The followingcrosses were made:(i) L H/L H × l h/l h → F1(ii) L h/L h × l H/l H → F1If the F1’s from cross i and cross ii are crossed,a. what proportion of the progeny are expected to bel h/l h?b. what proportion of the progeny are expected to beL h/l h?
6.5 Distinguish between cis and trans allele arrangements.
6.4 Write genotypes correctly to indicate if two genes are linked or not and if linked, the arrangement of the alleles on homologues.
7.18 In Drosophila, the genes st (scarlet eyes), ss (spineless bris- tles), and e (ebony body) are located on chromosome 3, with map positions as indicated: SS e 58 70 st 44 Each of these mutations is recessive to its wild-type allele (st+, dark red eyes; sst, smooth bristles; et, gray body). Phenotypically wild-type females with the genotype st ss et/st stt sste were crossed with triply recessive males. Predict the phenotypes of the progeny and the frequen- cies with which they will occur assuming (a) no interfer- ence and (b) complete interference.
What is the Characteristic pedigree for mitochondrial disease?
1. The figure below shows a pedigree examining the presence of a genetic disorder across multiple generations of a family. Based off this figure, answer the following questions prompted: || IV 3 9 10 5 2 C 6 11 T 7 12 8 15 13 16 14 17 d) What is the genotype for individual #4 in this family pedigree? ||| c) Why are no family members identified as a carrier of this genetic disorder? Figure Key a) Using the figure key provided, identify which members of this family are affected by this genetic disorder in each generation. (Be sure to include sex and generation number for each individual identified). b) Is this an autosomal recessive, autosomal dominant, or sex-linked genetic disorder? Explain. Unaffected Female Unaffected Male Affected Female ||| Affected Male Female Carrier Male Carrier
Some rare human genetic disorders have an inheritance pattern similar to the one seen in the pedigree below. I. 0O,0 II. IV. a.) How would you describe this mode of inheritance? b.) How would you explain the genetic nature of this rare disorder?
3.9 How many different kinds of F, gametes, F, genotypes, and F, phenotypes would be expected from the following crosses: (а) АА Х аа; (b) АА ВВ Х aa b; (c) АA ВВ СС Х аа bb cc? (d) What general formulas are suggested by these answers? ANS: F, Gametes F, Genotypes F, Phenotypes (a) 2 2 (b) 2 × 2 = 4 3 X 3 = 9 2 X 2 = 4 (c) 2 × 2 × 2 = 8 3 × 3 × 3 = 27 2 × 2 × 2 = 8 2", where n is the number of genes (d) 2" 3" 3.
An unaffected woman for a human disorder marries and unaffected man and they have children. This results in 3 affected sons, and one unaffected daughter, which ends up having children later on with an unaffected man and has 2 affected sons. A) Draw a simple pedigree diagram for this family, including a legend. B) What is the likely mode of inheritance of this trait: Please explain C) Provide the genotypes of the original mother and the daughter. Use a capital letter for the dominant allele and lowercase letter for the recessive allele. D) If one of the affected sons from the original marriage marries a 2nd cousin that is a carrier of this trait and has children, what is the probability that they will have 3 affected sons?
A rare blinding disease that has a relation to dengenerative factors is partially penetrant. In the following pedigrees for two families, the affected symptomatic individuals (black circles and squares) have been diagnosed with this disease due to the mutation in mitochondrial DNA m.14484T>C. If III.4 is homoplasmic for m.14484T>C in hair, blood, urine and other tissues examined. What will occur with IV.7 then?

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