12.46 A three-generation pedigree for a particularhuman trait is shown in the following figure:Generation:I1 2II1 234III1 2 34 5a. What is the mechanism of inheritance for the trait?b. Which persons in the pedigree are known to be het-erozygous for the trait?c. What is the probability that III-2 is a carrier (het-erozygous)?d. If III-3 and III-4 marry, what is the probability thattheir first child will have the trait?

a.) Autosomal recessive because an affected child appeared even if none of the parents were…

Answered: 12.46 A three-generation pedigree for a…

Human Heredity: Principles and Issues (MindTap Course List)

11th Edition

ISBN:9781305251052

Author:Michael Cummings

Publisher:Michael Cummings

Chapter11: Genome Alterations: Mutation And Epigenetics

Section: Chapter Questions

Problem 16QP: Familial retinoblastoma, a rare autosomal dominant defect, arose in a large family that had no prior...

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Explain why it is possible for the proband in the following pedigree to have children of blood types A, B, and AB. Considering epistatic genes, what are the possible genotypes of II-2?
A rare blinding disease that has a relation to dengenerative factors is partially penetrant. In the following pedigrees for two families, the affected symptomatic individuals (black circles and squares) have been diagnosed with this disease due to the mutation in mitochondrial DNA m.14484T>C. If III.4 is homoplasmic for m.14484T>C in hair, blood, urine and other tissues examined. What will occur with IV.7 then?
7.7 Genes a and b are 20 cM apart. An a* b*la* b* individual was mated with an a bla b individual. (a) Diagram the cross and show the gametes produced by each parent and the genotype of the F₁. (b) What gametes can the F, produce, and in what proportions? (c) If the F, was crossed to a bla b individuals, what off- spring would be expected, and in what proportions? (d) Is this an example of the coupling or repulsion link- age phase? (e) If the F, were intercrossed, what offspring would be expected, and in what proportions?
Hemophilia A is caused by a sex-linked recessive gene in human and in dogs. a. What proportions (and sexes), among their offspring will be hemophiliacs if a hemophilic male is mated to a homozygous nonhemophilic female?b. If a daughter produced by the mating in (a) is mated to a normal male, what proportions and (sexes) will be hemophilic among their offspring?
3.15 The pedigree shown here is for a rare autosomal recessive trait with complete penetrance. You may assume that no one in the pedigree has the recessive allele unless that person inherits it from either I-1 or II-4 or both.
3.11 The accompanying gel diagram shows the banding patterns observed among the progeny of a crossS between double heterozygous genotypes shown at the left (P1 and P2). On the right are shown the pat- emoterns of bands observed among the progeny. The P60r bands are numbered 1-4.
Shown below is a pedigree for Phenylketonuria (PKU), an autosomal recessive metabolic disorder. The characteristic feature of PKU is severe mental retardation A) What is the probability that individual II-1 is heterozygous for this gene? B) What is the probability that individual III-4 is heterozygous for this gene? C) If individuals III-3 and III-4 were to marry, what is the probability that their child would express PKU?
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3. 4 genes contribute to cobra length. The base (minimum) length is 6 feet for aabbccdd and the maximum length is 14 feet for AABBCCDD. Note: no Pascal's triangle is needed for this problem. a) Assuming all genes act equally to each other, how much does each capital letter allele add to the length? b) If you cross an AaBbCcdD cobra X an AaBBCcdd cobra, what are the minimum and maximum lengths of the offspring (once they grow up)? Show the genotypes for the min and max.
6.4 Write genotypes correctly to indicate if two genes are linked or not and if linked, the arrangement of the alleles on homologues.
Consider the following pedigree. Solid symbols represent individuals affected by the trait. Assume complete penetrance and non-variable expressivity. II 3 4 III 1 2 3 5 6 a) what is the mode of inheritance of this trait? b) Does the ratio of affected to unaffected offspring in generation III-1 to 1II-4 match the expected ratio for this mode of inheritance? Explain your answer in terms of the expected ratio versus the ratio observed. Give a reason for your answer. No mark is assigned for yes or no)
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