11. For a reaction A + B → P +Q, which is catalyzed by an enzyme (E), the following observations aremade: i) a AEB complex is formed during the reaction; ii) The product Q is always released before theproduct P is released. Based on the observations, the mechanism of the reaction is:A. Random mechanismB. Ping-pong mechanismC. Both A and BD. Neither A nor B

A)First understand both the mechanismPing-pong mechanism- In this type of reaction proceeds through…

Answered: 11. For a reaction A + B → P +Q, which…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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A noncompetitive inhibition is best overcome (or reversed) by: A. Increasing [enzyme] B. Increasing [product] C. Increasing [Substrate] D. All of the above
8. Which of the following is characteristic of a competitive inhibitor of an enzyme-catalyzed reaction? A. The inhibitor binds covalently to the enzyme. B. The inhibitor increases the substrate binding affinity to the enzyme. C. In the presence of the inhibitor, the reaction exhibits an apparent increase in Km. D. In the presence of the inhibitor, the reaction exhibits an apparent decrease in Vmax- E. Increasing the substrate concentration fails to overcome the effects of the inhibitor.
1. For enzymatic reaction, a mechanism was proposed by Michaelis and Menten as follows: ES k, and k,' ES à E and P k,. E + S a. Use steady state assumption, derive expression for the reaction rate. Where E is concentration of enzyme, S substrate, ES complex of E and S, E = E, – ES. (If you have difficulty in doing it, please consult lecture note) b. Assume K = 0.038 mol.L' at 25 °C, when the substrate concentration is 0.156 Mol.L', the rate of the reaction is 1.21 m mol/L.s. The maximum rate of conversion reaction is reached at high substrate concentrations. Calculate the maximum rate of this enzyme catalyzed reaction.
Which of the following is NOT true about enzymes A. they do not alter reaction equilibria B. they accelerate the forward rate of a reaction C. they decrease ∆G’0 of a reaction D. they accelerate the reverse rate of a reaction E. they stabilize transition states
26. AN ORGANIC COFACTOR IN A CONJUGATED ENZYME?A. NEITHER VITAMINS NOR MINERALSB. MINERALS C. VITAMINSD. BOTH VITAMINS AND MINERALS 27. WHICH OF THE FOLLOWING STATEMENTS CONCERNING COFACTORS IS INCORRECT?A. VITAMINS CANNOT BE COFACTORSB. SOME COFACTORS ARE METAL IONS C. COFACTOR IS THE NON-PROTEIN PORTION OF ENZYME D. CONJUGATED ENZYMES CONTAIN COFACTORS 28. WHICH OF THE FOLLOWING VITAMINS IS NOT A FAT SOLUBLE VITAMIN? A. VITAMIN E B. VITAMIN C C. VITAMIN A D. VITAMIN D 29. WHAT HAPPENS TO SUBSTRATE MOLECULES AT AN ENZYME ACTIVE SITE?A. ALWAYS REACT WITH OXYGEN B. UNDERGO CHANGE TO A DESIRED PRODUCTS C. BECOME CATALYST C ALWAYS REACT WITH OXYGEN B UNDERGO CHANGE TO A DESIRED PRODUCT D. BECOME COVALENTLY BONDED TO THE ENZYME D. BECOME COVALENTLY BONDED TO THE ENZYME 30. ACTION OF CHEMICAL WARFARE AND ORGANOPHOSPHATE INSECTICIDE ARE BASED ON?A. REVERSIBLE ENZYME INHIBITOR B. IRREVERSIBLE ENZYME INHIBITOR C. REVERSIBLE ENZYME ACTIVATOR D. IRREVERSIBLE ENZYME ACTIVATOR
4. Consider the reaction: OH CH H3C O C H₂ a. What kind of reaction is being performed here? H3C C H₂ b. What enzyme performs this reaction? c. What cofactors, if any, are required for this reaction?
Consider the two reactions below. They are fast and have reached equilibrium by the end of the time shown. At time zero (t = 0) which is true? [Product] (M) I 2 1 Time The AG of reaction 1 is greater (more positive) than the AG of reaction 2. The AG of reaction 1 is less (more negative) than the AG of reaction 2. ○ The AG of reaction 1 is equal to the AG of reaction 2.
6. Consider the reaction: H H SCOA a. What kind of reaction is being performed here? b. What enzyme performs this reaction? c. What cofactors, if any, are required for this reaction? H H SCOA
Consider the mechanism below. (i) Identify Asp X's function in the first step of the reaction. Expla how you determined this and why Asp X's function is increasing the rate. (ii) Identify Asp X's fu in the second step of the reaction. (iii) For His D, explain how it contributes to the reaction and why that contribution increases the reaction rate. Asp X o HN Asp X o N. N. H. Coo His D Co0o-H His D OR HO, O. LOR HO. HO- но. HN Asn N HN Asn N ndn Asp Z Asp Z
1. Activatotrs are types of A. inhibitor B. cofactor C. enzyme D. substrate 2. Which of the following does NOT affect enzyme selectivity ? A. Electrostatic interactions B. Molecular shape C. hydrophillic Interactions D. None of these answers are correct
Which of the following statement about the enzyme thermodynamics is TRUE? a. Enzymes increase the activation barrier (∆G cat) of the products b. Enzymes decrease the activation barrier (∆G cat) of the products c. Enzymes decrease the free energy (∆G) of the products d. Enzymes decrease the free energy (∆G) of the reactants e. Enzymes increase the activation barrier (∆G cat) of the reactants
7

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