10.18 Using the information in Figs. 10.14 and 10.18, explain how the two oligonucleotides 5'-CAAAGAAAAG-3' and 5'-CTTTTCTTTG-3' assemble into a double helical structure (see Fig. 10.14 for the 3' and 5' numbering, and definitions of C, A, G and T).
10.18 Using the information in Figs. 10.14 and 10.18, explain how the two oligonucleotides 5'-CAAAGAAAAG-3' and 5'-CTTTTCTTTG-3' assemble into a double helical structure (see Fig. 10.14 for the 3' and 5' numbering, and definitions of C, A, G and T).
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
Related questions
Question
![10.18 Using the information in Figs. 10.14 and
10.18, explain how the two oligonucleotides
5'-CAAAGAAAAG-3' and 5'-CTTTTCTTTG-3'
assemble into a double helical structure (see Fig.
10.14 for the 3' and 5' numbering, and definitions
of C, A, G and T).
Fig. 10.18. Two strands of oligonucleotides sequenced
5-CAAAGAAAAG-3' and 5'-CTTTTCTTTG-3' assemble into a
double helix. The structure has been determined by X-ray diffraction
[M. L. Kopka et al. (1996) J. Mol. Biol., vol. 334, p. 653]. The
backbone of each oligonucleotide is depicted as an arrow pointing
towards the C3' end of the sequence, and the nucleobases are shown in
a 'ladder' representation. The nucleobases are colour coded: G, green;
A, red; C, purple; T, turquoise.](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2F00a3542e-c679-4030-a1b6-c1552b026fb7%2F367ba056-bfbe-47d7-b809-88573b31b37a%2Fexj38bb_processed.png&w=3840&q=75)
Transcribed Image Text:10.18 Using the information in Figs. 10.14 and
10.18, explain how the two oligonucleotides
5'-CAAAGAAAAG-3' and 5'-CTTTTCTTTG-3'
assemble into a double helical structure (see Fig.
10.14 for the 3' and 5' numbering, and definitions
of C, A, G and T).
Fig. 10.18. Two strands of oligonucleotides sequenced
5-CAAAGAAAAG-3' and 5'-CTTTTCTTTG-3' assemble into a
double helix. The structure has been determined by X-ray diffraction
[M. L. Kopka et al. (1996) J. Mol. Biol., vol. 334, p. 653]. The
backbone of each oligonucleotide is depicted as an arrow pointing
towards the C3' end of the sequence, and the nucleobases are shown in
a 'ladder' representation. The nucleobases are colour coded: G, green;
A, red; C, purple; T, turquoise.
Transcribed Image Text:to next sugar
to next sugar
H.
p=0
N-H IIO
Me
5'
N H-N
to next
phosphate
to next
phosphate
Adenine-thymine (A-T) base pair
to next sugar
to next sugar
O.
H
O H-N
= nucleobase
N-H IN
(A, T, G or C)
to next
phosphate
N-H O
to next
H
phosphate
Guanine-cytosine (G-C) base pair
Fig. 10.14. The left-hand diagram shows two units in one strand of DNA; DNA is composed of condensed deoxyribonucleotides and the four
possible nucleobases are adenine (A), guanine (G), cytosine (C) and thymine (T).
The right-hand diagrams illustrate how complementary base pairs in adjacent strands in DNA interact through hydrogen bonding. (See also
Fig. 10.18.)
Expert Solution
This question has been solved!
Explore an expertly crafted, step-by-step solution for a thorough understanding of key concepts.
This is a popular solution!
Trending now
This is a popular solution!
Step by step
Solved in 2 steps
Recommended textbooks for you
Biochemistry
Biochemistry
ISBN:
9781319114671
Author:
Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:
W. H. Freeman
Lehninger Principles of Biochemistry
Biochemistry
ISBN:
9781464126116
Author:
David L. Nelson, Michael M. Cox
Publisher:
W. H. Freeman
Fundamentals of Biochemistry: Life at the Molecul…
Biochemistry
ISBN:
9781118918401
Author:
Donald Voet, Judith G. Voet, Charlotte W. Pratt
Publisher:
WILEY
Biochemistry
Biochemistry
ISBN:
9781319114671
Author:
Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:
W. H. Freeman
Lehninger Principles of Biochemistry
Biochemistry
ISBN:
9781464126116
Author:
David L. Nelson, Michael M. Cox
Publisher:
W. H. Freeman
Fundamentals of Biochemistry: Life at the Molecul…
Biochemistry
ISBN:
9781118918401
Author:
Donald Voet, Judith G. Voet, Charlotte W. Pratt
Publisher:
WILEY
Biochemistry
Biochemistry
ISBN:
9781305961135
Author:
Mary K. Campbell, Shawn O. Farrell, Owen M. McDougal
Publisher:
Cengage Learning
Biochemistry
Biochemistry
ISBN:
9781305577206
Author:
Reginald H. Garrett, Charles M. Grisham
Publisher:
Cengage Learning
Fundamentals of General, Organic, and Biological …
Biochemistry
ISBN:
9780134015187
Author:
John E. McMurry, David S. Ballantine, Carl A. Hoeger, Virginia E. Peterson
Publisher:
PEARSON