Given the following peptide SEPLMAPVEYPK TABLE 5.1 Properties of the common amino acids found in proteins PK, of lonizing Side Chain Name Abbreviations: pK₂ of PK of 1- and 3-letter a-COOH a-NH3+ codes Group Group Alanine A, Ala 2.3 9.7 Arginine R, Arg 2.2 9.0 Asparagine N, Asn 2.0 8.8 Aspartic acid D, Asp 2.1 9.8 Cysteine C, Cys 1.8 10.8 Glutamine 2.2 9.1 Glutamic acid 2.2 9.7 G, Gly 2.3 9.6 1.8 9.2 Glycine Histidine Isoleucine Leucine Lysine H, His I, Ise 2.4 9.7 L, Leu 2.4 9.6 K, Lys 2.2 9.0 Methionine M, Met 2.3 9.2 Phenylalanine F, Phe 1.8 9.1 P, Pro 2.0 10.6 S, Ser 2.2 9.2 Threonine T, Thr 2.6 10.4 W, Trp 2.4 9.4 Tryptophan Tyrosine Y, Tyr 2.2 9.1 2.3 9.6 Valine V, Val "Approximate values found for side chains on the free amino acids. W.P. Jencks and J. Regenstein (1976) lonization constants of acids and bases in Handbook of Biochemistry and Molecular Biology, 3rd ed., G. Fasman (ed.), CRC Press, Boca Raton, FL. Proline Serine Q, Gln E, Glu - 12.5 - 3.9 8.3 4.2 6.0 - 10.0 - 10.1 Part A Estimate the net charge at pH=7. Assume the pK, values given in the table above. Express your answer as an integer. 195] ΑΣΦ 3 → Submit Request Answer Part B Estimate the net charge at pH= 12. Assume the pKa values given in the table above. Express your answer as an integer. VΠΙ ΑΣΦ Submit ▸ Part C Request Answer Part D Complete previous part(s) Provide Feedback ? ?
Given the following peptide SEPLMAPVEYPK TABLE 5.1 Properties of the common amino acids found in proteins PK, of lonizing Side Chain Name Abbreviations: pK₂ of PK of 1- and 3-letter a-COOH a-NH3+ codes Group Group Alanine A, Ala 2.3 9.7 Arginine R, Arg 2.2 9.0 Asparagine N, Asn 2.0 8.8 Aspartic acid D, Asp 2.1 9.8 Cysteine C, Cys 1.8 10.8 Glutamine 2.2 9.1 Glutamic acid 2.2 9.7 G, Gly 2.3 9.6 1.8 9.2 Glycine Histidine Isoleucine Leucine Lysine H, His I, Ise 2.4 9.7 L, Leu 2.4 9.6 K, Lys 2.2 9.0 Methionine M, Met 2.3 9.2 Phenylalanine F, Phe 1.8 9.1 P, Pro 2.0 10.6 S, Ser 2.2 9.2 Threonine T, Thr 2.6 10.4 W, Trp 2.4 9.4 Tryptophan Tyrosine Y, Tyr 2.2 9.1 2.3 9.6 Valine V, Val "Approximate values found for side chains on the free amino acids. W.P. Jencks and J. Regenstein (1976) lonization constants of acids and bases in Handbook of Biochemistry and Molecular Biology, 3rd ed., G. Fasman (ed.), CRC Press, Boca Raton, FL. Proline Serine Q, Gln E, Glu - 12.5 - 3.9 8.3 4.2 6.0 - 10.0 - 10.1 Part A Estimate the net charge at pH=7. Assume the pK, values given in the table above. Express your answer as an integer. 195] ΑΣΦ 3 → Submit Request Answer Part B Estimate the net charge at pH= 12. Assume the pKa values given in the table above. Express your answer as an integer. VΠΙ ΑΣΦ Submit ▸ Part C Request Answer Part D Complete previous part(s) Provide Feedback ? ?
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
Related questions
Question
52.1.1
Transcribed Image Text:### Analysis of a Peptide Sequence and Amino Acid Properties
**Peptide Sequence:** SEPLMAPVEYPK
#### Table 5.1: Properties of Common Amino Acids Found in Proteins
| Name | Abbreviations (1-letter and 3-letter codes) | \(pK_a\) of \(\alpha\)–COOH Group | \(pK_a\) of \(\alpha\)–NH\(_3^+\) Group | \(pK_a\) of Ionizing Side Chain |
|-----------------|------------------------------------------|----------------------|----------------------|--------------------|
| Alanine | A, Ala | 2.3 | 9.7 | - |
| Arginine | R, Arg | 2.2 | 9.0 | 12.5 |
| Asparagine | N, Asn | 2.0 | 8.8 | - |
| Aspartic acid | D, Asp | 2.1 | 9.8 | 3.9 |
| Cysteine | C, Cys | 1.8 | 10.8 | 8.3 |
| Glutamine | Q, Gln | 2.2 | 9.1 | - |
| Glutamic acid | E, Glu | 2.2 | 9.7 | 4.2 |
| Glycine | G, Gly | 2.3 | 9.6 | - |
| Histidine | H, His | 1.8 | 9.2 | 6.0 |
| Isoleucine | I, Ile | 2.4 | 9.7 | - |
| Leucine | L, Leu | 2.4 | 9.6 | - |
| Lysine | K, Lys | 2.2 | 9.0 | 10.0 |
| Methionine | M, Met | 2.1 | 9.3 | - |
| Phenylalanine | F, Phe |
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