1. The desire steady state concentration of a drug is 5mg/l. Clearance of the drug is 30 1/hr and its volume of distribution is 1501. a) What infusion rate will be necessary to reach the target concentration? b) How long will it take to reach steady state? c) What loading dose will be required to instantaneously achieve the steady state?

1. The desire steady state concentration of a drug is 5mg/l. Clearance of the drug is 30 1/hr and its volume of distribution is 1501. a) What infusion rate will be necessary to reach the target concentration? b) How long will it take to reach steady state? c) What loading dose will be required to instantaneously achieve the steady state?

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

See similar textbooks

Similar questions

What are the safety guidelines for vincristine preparation and administration? A. Use an infusion pump to administer intravenously over 25-50 minutes. B. Prepare in a minibag and infuse intravenously over 5-15 minutes. C. Dilute in a 10ml syringe with normal saline and administer IV push. D. Reconstitute in a minibag of 5% dextrose in water and administer IV push.
Increased blood pressure A) Epinephrine B) Isoproterenol C) Phenylephrine D) Physostigmine E) Tyramine Control Prazosin X Cocaine X Time 161. Drug X is injected intravenously into three subjects (including one control subject). The control subject is not pretreated, whereas the other two subjects are pretreated with either prazosin or cocaine. Blood pressure is recorded directly from the brachial artery (see graph). Drug X is most likely which of the following? 4 X
54. The volume of distribution of a drug is 350 L. Which of the following is most likely to account for this volume of distribution? OA) Extensive binding to tissue proteins B) Extensive hepatic metabolism C) Inability to cross the blood-brain barrier D) Low lipid solubility E) Rapid renal excretion
. At therapeutic range, theophylline follows linear pharmacokinetics. The average t1/2 is 3.4 hours, and the average volume of distribution is 30 L. What is the average clearance for theophylline assuming a one-compartment model?
Polymer nanoparticles, Microparticles and hydrogels have been developed for slow and sustained drug release for slow and sustained drug release application; mark all that apply below: 1)Drug release from hydrogels can be via (a) drug diffusion, (b) degradation of the polymeric matrix and (c) swelling 2) PLGA degrades to lactic acid and glycolic acid, which are not biocompatible 3) Drug release can be triggered through internal and external stimuli - I.e. by use of pH labile chemistries or external triggers 4) Burst release describes the initial faster release rates often observed in drug delivery system, which is then followed by sustained release 5) while burst release is observed with polymer nanoparticles, it is not observed from hydrogels
Pls help
Which one of these is NOT a possible justification for formulating medicines of the active pharmaceutical ingredient (API) and various expcipients? a) The API is stabilised by excipients to avoid appreciable degradation before administration b) The possibility of irritation to the body by API is reduced by the excipients c) A phatmalogical effect is exerted by both API and excipients d) The API cannot be used undiluted as it is very potent
33) Your patient has a chronic history of congestive heart failure and does not currently have pulmonary edema. Why is administration of a beta blocker beneficial to this patient? A) Beta blockers may help reduce the risk of blood clotting B) Beta blocker administration is not beneficial to this group C) Because beta blocker manufacturers pay you a lot of money to administer them D) Beta blockers minimize the risk of hypertrophic heart disease 34) If the patient in #33 had pulmonary edema, why could beta blocker administration be detrimental? A) The blood pressure could be lowered B) More fluid would back up into the lungs C) It would increase risk of blood clotting D) Beta blocker administration is indicated in this patient
When calculating creatinine clearance using the MDRD equation (eGFR), which of the following factors are considered? Question 18 options: A) verification that the patient has been fasting B) identification of ethnicity C) body mass D) time of day of blood collection E) physical workout schedule of the patient
When recommending a dose of 800mg of Ibuprofen PO for emergency pain relief, you should advise your patient to avoid ________________. A) Diuretics B) Alcohol C) Opiates D) Blood Pressure Medicine
What is a normal Hb value for an adult woman? a) 36 - 46% b) 12.0 - 16.0 g / dL c) 5.0 - 12.0 g / dL d) 45 - 52% e) 16.0 - 20.0 g / dL
13) Which of the following best describes the mechanism of an antiplatelet medication? A) Inhibition of platelet aggregation B) Blocking of sodium channels C) Inhibition of the inflammatory response D) Inhibition of factor X conversion