1. The desire steady state concentration of a drug is 5mg/l. Clearance of the drug is 30 1/hr and its volume of distribution is 1501. a) What infusion rate will be necessary to reach the target concentration? b) How long will it take to reach steady state? c) What loading dose will be required to instantaneously achieve the steady state?

Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
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Chapter1: Biochemistry: An Evolving Science
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1. The desire steady state concentration of a drug is 5mg/l. Clearance of the drug is
30 1/hr and its volume of distribution is 1501.
a) What infusion rate will be necessary to reach the target concentration?
b) How long will it take to reach steady state?
c) What loading dose will be required to instantaneously achieve the steady state?
Transcribed Image Text:1. The desire steady state concentration of a drug is 5mg/l. Clearance of the drug is 30 1/hr and its volume of distribution is 1501. a) What infusion rate will be necessary to reach the target concentration? b) How long will it take to reach steady state? c) What loading dose will be required to instantaneously achieve the steady state?
2. Drug X 100mg is administered as an intramuscular injection and has the following
pharmacokinetic parameters:
ti = 8hrs
ka = 1.5hr-1
V = 101
%3D
F = 65%
What will be the concentration at 12hrs after the dose is administered?
Transcribed Image Text:2. Drug X 100mg is administered as an intramuscular injection and has the following pharmacokinetic parameters: ti = 8hrs ka = 1.5hr-1 V = 101 %3D F = 65% What will be the concentration at 12hrs after the dose is administered?
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