1. Predict Products. Using line structures, give the major product. Rearrangements are possible. DON'T SHOW MECHANISMS HERE. Use scratch paper if needed. NR if no reaction; indicate stereochemistry as we have discussed (E=enantiomer; D = Diastereomer) HCI a hot HCI cold Br2 FeBr3 HNO3 d. H2SO4 CI NR is not this answer. AICI3
Reactions of Ethers
Ethers (R-O-R’) are compounds formed by replacing hydrogen atoms of an alcohol (R-OH compound) or a phenol (C6H5OH) by an aryl/ acyl group (functional group after removing single hydrogen from an aromatic ring). In this section, reaction, preparation and behavior of ethers are discussed in the context of organic chemistry.
Epoxides
Epoxides are a special class of cyclic ethers which are an important functional group in organic chemistry and generate reactive centers due to their unusual high reactivity. Due to their high reactivity, epoxides are considered to be toxic and mutagenic.
Williamson Ether Synthesis
An organic reaction in which an organohalide and a deprotonated alcohol forms ether is known as Williamson ether synthesis. Alexander Williamson developed the Williamson ether synthesis in 1850. The formation of ether in this synthesis is an SN2 reaction.
![### Predicting Products in Organic Reactions
**Instructions:**
Using line structures, give the major product for each of the following reactions. Rearrangements are possible. **Do not show mechanisms here**. Use scratch paper if needed. NR if no reaction; indicate stereochemistry as we have discussed (E = enantiomer; D = diastereomer).
#### Reactions:
**a.**
\[ \text{CH}_3-CH=CH-CH_3 \xrightarrow{\text{HCl, hot}} ? \]
**b.**
\[ \text{CH}_3-CH=CH-CH_3 \xrightarrow{\text{HCl, cold}} ? \]
**c.**
![Benzene ring] \xrightarrow{\text{Br}_2, \text{FeBr}_3} ? \]
**d.**
![T-butanol with benzene ring] \xrightarrow{\text{HNO}_3, \text{H}_2\text{SO}_4} ? \]
**e.**
![Methoxy benzene] \xrightarrow{\text{tert-butyl chloride, AlCl}_3} ? \]
Note: NR is not the answer for any of these reactions.
### Additional Explanation:
- **Reaction a and b:** Focuses on the addition of HCl to an alkene. The condition (hot and cold) can impact the product structure.
- **Reaction c:** Aromatic bromination using Br₂ and FeBr₃, a common electrophilic aromatic substitution.
- **Reaction d:** Nitration using HNO₃ and H₂SO₄, another example of electrophilic aromatic substitution.
- **Reaction e:** Friedel-Crafts alkylation using tert-butyl chloride and AlCl₃.
**Remember:**
- Rearrangements can affect the carbon skeleton in some reactions.
- Consider the conditions (hot or cold) to predict the regioisomer formed in a and b.
- Use scratch paper to verify your line structures match the expected major products.](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2F9881b937-b6f3-4fcd-95a2-fb7295b9c7b9%2F42b1fcd4-8a45-4330-a88c-e3fcea420fdd%2F91853d_processed.jpeg&w=3840&q=75)
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