1. If neither Viagra or ginseng works to fix the cat's problem,  what protein(s) would you suspect is “broken” in this signalling pathway? 2. Why?

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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1. If neither Viagra or ginseng works to fix the cat's problem,  what protein(s) would you suspect is “broken” in this signalling pathway?

2. Why?

Smooth Muscle
Cell
Nitroglycerin
Guanylyl Cyclase
(inactive)
Nitric Oxide .
GTP
N:O-Guanylyl Cyclase
(active)
Nitric Oxide
CGMP
Inactive PKG
(N:O)
fCitrulline
Activated PKG
ATP
Nitric
Oxide
Synthase
Proteins
Phospho-Proteins
Ca2
Сам
Lowering of Ca²*
Desensitization to Ca2+
L-Arginine
Endothelial
Or Neuronal
Cell
Relaxation
Transcribed Image Text:Smooth Muscle Cell Nitroglycerin Guanylyl Cyclase (inactive) Nitric Oxide . GTP N:O-Guanylyl Cyclase (active) Nitric Oxide CGMP Inactive PKG (N:O) fCitrulline Activated PKG ATP Nitric Oxide Synthase Proteins Phospho-Proteins Ca2 Сам Lowering of Ca²* Desensitization to Ca2+ L-Arginine Endothelial Or Neuronal Cell Relaxation
LOCALLY PRODUCED
NITRIC OXIDE
Ca2*
EXPORT
PDE5
INHIBITORS
Ca2+
SEQUESTRATION,
Ca2+
RELEASE
5'-GMP
GC
P'Lamban
GTP
IP3
Receptor
Ca2+
PDE5
KCGMP
PKG
MLC P'tase
MLC
MLC-P
MLCK
RELAXATION
CONTRACTION
BK K* CHANNEL
Transcribed Image Text:LOCALLY PRODUCED NITRIC OXIDE Ca2* EXPORT PDE5 INHIBITORS Ca2+ SEQUESTRATION, Ca2+ RELEASE 5'-GMP GC P'Lamban GTP IP3 Receptor Ca2+ PDE5 KCGMP PKG MLC P'tase MLC MLC-P MLCK RELAXATION CONTRACTION BK K* CHANNEL
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