1. For each of the following statements, indicate whether they are true of false.• enamines are more nucleophilic than enols - it follows the trend of N being a better pi donorthan O.• enolates are wa-a-a-a-ay better nucleophiles than enamines - unlike enols, enolates have a fullnegative charge.• the nitro group (NO2) can be understood to be the strongest of the common electronwithdrawing groups by virtue of the pk, value of simple nitroalkanes (ca. 8.5).⚫ typical "thermodynamic conditions" for the formation of enolates are: LDA, THF, -78 °C.⚫ the aldol reaction and the aldol condensation are one and the same - these terms can be usedinterchangeably.⚫ the aldol reaction was discovered in 1894 by Prof. Al Doll at Hudson University.• naming organic reactions after people is a questionable practise, which should be abolished.• naming organic reactions after people is a laudable practise, which should be continued.⚫ the E1CB mechanism goes through a carbocation intermediate.2. Write a complete mechanism for the reaction shown below. ི་ ་ ི་2. H₂O'

Answered: Image /qna-images/answer/dd7d5893-9e54-4058-93b1-9cfd54edc73a.jpg

Answered: 1. For each of the following…

Organic Chemistry: A Guided Inquiry

2nd Edition

ISBN:9780618974122

Author:Andrei Straumanis

Publisher:Andrei Straumanis

Chapter14: Elimination

Section: Chapter Questions

Problem 18E

See similar textbooks

Similar questions

2. The structures of alkenes can affect their reactivity in the reaction with H-Br. H;C H H;C H H H H `H H;C `H H `H A B (a) Arrange the reactivity of above alkenes (A, B and C) in an increasing order. AL (b) Use the carbocation formation to show the ease of alkenes to accept a proton from HBr.
Ql- Arrange the following carbonium ion as more stable. Why? Me Me „Me A C Q2- Choose the substituted group that makes the following reaction faster. Why? X- CH2 H X- ососн, OR COOCH} Y= NH2 OR NO2 Q3- Which of the following compounds give the highest yield when reacting with a carbonyl compound. Why? NH 2 NH2 NH2 Me Me Me OR OR NO 2 NO2 NO2
For each of the reactions indicate which reactant is the nucleophile and which is the electrophile.
How would you synthesize the following compounds from cyclohexanone using reagents from the table? Use letters from the table to list reagents in the order used (first at the left). Reagents a 1. CH3MgBr/dry ether 2 H3O+ e 1. OsO4 i 1. BH3/THF 2. NaHSO3/H2O 2. H₂O₂ / NaOH b 1. C6H5MgBr / dry ether f 1. NaBH4 j Mg / dry ether 2 H3O+ 2. H3O+ с PBr3 g HOCH2CH2OH/HCI k H2/Pd d m-chloroperbenzoic h H3O+ / heat I CrO3 / H3O+ acid m cyclohexanone a) cyclohexylbenzene b) 2-phenylcyclohexanone Submit Answer Try Another Version 3 item attempts remaining
How would you synthesize the following compounds from cyclohexanone using reagents from the table? Use letters from the table to list reagents in the order used (first at the left). Reagents a 1. CH3MgBr / dry ether 2 H3O+ e 1. OsO4 i 1. BH3/THF 2. NaHSO3/H₂O 2. H₂O₂ / NaOH b 1. C6H5 MgBr / dry ether f 1. NaBH4 j Mg / dry ether 2 H3O+ 2. H3O+ C PBг3 g HOCH2CH2OH/HCI k H2/Pd d m-chloroperbenzoic h H3O+ / heat 1 CrO3 / H3O+ acid a) 2-phenylcyclohexanone b) cyclohexylbenzene m cyclohexanone
Recognising how resonance contribtutes to the arrangement of charge around a ring helps to understand the reactivity of a substituted benzene. Consider the resonance contributors of ethoxybenzene 8-1 8-5-5 e According to resonance, is the ring: activated or deactivated to electrophilic substitution. And which site/s are the most susceptible to substitution? O a. deactivated - meta postions are most active O b. Deactivated - ortho and para positions are most active O c. Activated - ortho and para positions are most active O d. Activated - meta positions are most active
Draw the FULL electron-pushing mechanism for the reaction to synthesise Lidocaine, including ALL intermediates (with formal charges) and electron pushing arrows. label the electrophile and nucleophile in each step!
2.i) Draw the mxn for conversion of starting material A into methyl bromide and compound B upon heating at 60°C in THF for 1 day. Br A (C7H₁5BrOS) heat THF B OH + Me-Br ** What is the nucleophilic atom in the mxn's 1st step? ** What is the nucleophilic atom in the mxn's last step? ** What atom of the leaving group gains a lone pair in the mxn's last step? €
Part III, Reaction Mechanisms 16. (15 pts) Show the mechanism for the following transformation. осно aq NaOH H3O+ Мон + H3C-OH OH
Identify the electrophile and the nucleophile in each of the following reaction steps and then draw curved arrows to illustrate the bond-making and bondbreaking processes.
6. Provide reagents and intermediates in the indicated boxes to complete the reaction scheme. + H NaBH3CN, HCI (two steps, no acidic hydrolysis, from one product) 016H (w/o heat) 1. MeLi (xs) 2. HCI, H₂O NH₂ 1. Saponification 2. A 0 1. MeMgBr (xs) 2. HCI, H₂O 018 Me NH₂ 1. Dibal H, 2. H3O+ POCk3, pyr or + 1. LIAIH(O'Bu)3 (XS) 2. acidic workup
Consider the reaction. 1. NaBH4 2. D20 Complete the electron-pushing mechanism for the reaction by drawing the necessary organic structures and curved arrows for each step. Make sure to include all nonbonding electron pairs. Step 1: Add curved arrows for the first step, treatment with NaBH,. Treat Na* as a spectator ion. Na + H H В H

SEE MORE QUESTIONS

Recommended textbooks for you

Organic Chemistry: A Guided Inquiry

Chemistry

ISBN:

9780618974122

Author:

Andrei Straumanis

Publisher:

Cengage Learning

Organic Chemistry: A Guided Inquiry

Chemistry

ISBN:

9780618974122

Author:

Andrei Straumanis

Publisher:

Cengage Learning

SEE MORE TEXTBOOKS