Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
Section: Chapter Questions
Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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
Transcribed Image Text:**Grignard Reaction with Hexanal**
**Reactant:**
- The chemical structure on the left represents hexanal, an aldehyde with the formula C6H12O. It has a hexane chain with an aldehyde group (–CHO) at one end.
**Reagents:**
1. **Ethylmagnesium bromide (CH3CH2-MgBr):** This is a Grignard reagent used for nucleophilic addition to the aldehyde.
2. **Hydronium ion (H3O+):** Used in a subsequent step to protonate the resulting alkoxide, forming the alcohol.
**Reaction Mechanism:**
1. The Grignard reagent attacks the electrophilic carbon in the aldehyde group, forming a carbon-carbon bond.
2. The resulting alkoxide intermediate is then protonated by hydronium ions, resulting in an alcohol.
**Result:**
- The product of this reaction is a secondary alcohol, formed by the addition of an ethyl group from the Grignard reagent to the hexanal.
**Educational Explanation:**
This image illustrates a Grignard reaction, which is an essential tool in organic synthesis. Grignard reagents allow for the formation of carbon-carbon bonds, facilitating the conversion of aldehydes and ketones into alcohols. This reaction highlights the electrophilic nature of carbonyl carbons and the nucleophilic property of organomagnesium compounds. Understanding Grignard reactions is crucial for grasping complex synthetic pathways in organic chemistry.
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