Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
Section: Chapter Questions
Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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![The image contains a series of organic chemistry reactions demonstrating different chemical processes. Here's a detailed transcription and explanation of each reaction sequence:
1. **Epoxide Opening with Acid:**
- **Starting Material:** Epoxide (three-membered oxygen-containing ring attached to a cyclohexane).
- **Reagents:**
- Step 1: Water (H₂O)
- Step 2: Sulfuric acid (H₂SO₄)
- **Overview:** The epoxide ring is opened using water in the presence of sulfuric acid, which typically leads to a diol with anti-addition.
2. **Grignard Reaction with Epoxide:**
- **Starting Material:** Cyclopentane with a magnesium bromide (MgBr, a Grignard reagent).
- **Reagents:**
- Step 1: Epoxide
- Step 2: Hydrochloric acid (HCl) and Water (H₂O)
- **Overview:** The Grignard reagent attacks the less hindered carbon of the epoxide, opening the ring and forming an alcohol after acidic work-up.
3. **Hydroboration-Oxidation:**
- **Starting Material:** Cyclohexene.
- **Reagents:**
- Step 1: Borane (BH₃) in tetrahydrofuran (THF)
- Step 2: Hydrogen peroxide (H₂O₂), sodium hydroxide (NaOH), and water (H₂O)
- **Overview:** This reaction adds water across the double bond in a syn addition to form a primary alcohol.
4. **Dihydroxylation with Osmium Tetroxide:**
- **Starting Material:** Cyclohexene.
- **Reagents:**
- Step 1: Osmium tetroxide (OsO₄) in THF
- Step 2: Hydrogen sulfide (H₂S)
- **Overview:** This reaction results in the syn addition of two hydroxyl groups, transforming the alkene into a vicinal diol.
5. **Oxymercuration-Reduction:**
- **Starting Material:** Cyclohexene.
- **Reagents:**
- Step 1: Mercuric acetate [Hg(OAc)₂] in ethanol (CH₃CH₂OH)
- Step 2](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2Fc8ba0180-e83e-4516-bb9b-be23df49947d%2F1bfe6e66-181c-4631-890f-6010dbb7c23e%2F0xg93ru_processed.jpeg&w=3840&q=75)
Transcribed Image Text:The image contains a series of organic chemistry reactions demonstrating different chemical processes. Here's a detailed transcription and explanation of each reaction sequence:
1. **Epoxide Opening with Acid:**
- **Starting Material:** Epoxide (three-membered oxygen-containing ring attached to a cyclohexane).
- **Reagents:**
- Step 1: Water (H₂O)
- Step 2: Sulfuric acid (H₂SO₄)
- **Overview:** The epoxide ring is opened using water in the presence of sulfuric acid, which typically leads to a diol with anti-addition.
2. **Grignard Reaction with Epoxide:**
- **Starting Material:** Cyclopentane with a magnesium bromide (MgBr, a Grignard reagent).
- **Reagents:**
- Step 1: Epoxide
- Step 2: Hydrochloric acid (HCl) and Water (H₂O)
- **Overview:** The Grignard reagent attacks the less hindered carbon of the epoxide, opening the ring and forming an alcohol after acidic work-up.
3. **Hydroboration-Oxidation:**
- **Starting Material:** Cyclohexene.
- **Reagents:**
- Step 1: Borane (BH₃) in tetrahydrofuran (THF)
- Step 2: Hydrogen peroxide (H₂O₂), sodium hydroxide (NaOH), and water (H₂O)
- **Overview:** This reaction adds water across the double bond in a syn addition to form a primary alcohol.
4. **Dihydroxylation with Osmium Tetroxide:**
- **Starting Material:** Cyclohexene.
- **Reagents:**
- Step 1: Osmium tetroxide (OsO₄) in THF
- Step 2: Hydrogen sulfide (H₂S)
- **Overview:** This reaction results in the syn addition of two hydroxyl groups, transforming the alkene into a vicinal diol.
5. **Oxymercuration-Reduction:**
- **Starting Material:** Cyclohexene.
- **Reagents:**
- Step 1: Mercuric acetate [Hg(OAc)₂] in ethanol (CH₃CH₂OH)
- Step 2
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