1. Aldol reactions (condensation of two aldehydes or ketones to yield a ẞ-hydroxy carbonyl) can go inreverse (B-hydroxy carbonyl to two aldehyde/ketones, a retro-aldol). Propose mechanisms for thefollowing two transformations, using both intra-molecular aldol and a retro-aldol reactions. Be sureto follow the rules we have discussed for writing reaction mechanisms!H₂C.H&C.Na+ -OEtethanolH₂C-H₂C. HONa OEtethanol

However, I can provide some general information about these reactions and point you to some…

Answered: 1. Aldol reactions (condensation of two…

Organic Chemistry: A Guided Inquiry

2nd Edition

ISBN:9780618974122

Author:Andrei Straumanis

Publisher:Andrei Straumanis

Chapter26: Aldol And Claisen Reactions

Section: Chapter Questions

Problem 7E

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Nn.98. Subject :- Chemistry
Three reactions between a Grignard reagent and a carbonyl compound are given. Draw the main organic product for each reaction and indicate if H+ or H¯ is needed to complete each reaction. The starting material structures are provided in the answer fields as a starting point for your drawings. The first reaction involves a ketone. 1. CH₂MgBr 2. H+ or H™? Select Draw / |||||| C Rings O More Erase
Draw the structures A, B and C for the reaction sequence below.
4) When a mixture of two different compounds both containing a hydrogens are placed under acidic or basic conditions, crossed aldol products can be formed. By either self-condensation or cross condensations. Draw the 4 aldol and 4 a.B-unsaturated ketones that can be made from the following mixed system. -OH 4 products One way to control this is by either having only one compound with a hydrogens or by reacting the desired nucleophile with lithium diisopropylamide (LDA) before addition of second carbonyl. The issue here is that this reaction stops at the aldol unless excess base is used. он LDA OH heat Show a synthetic scheme of how to use the following carbonyls to control the formation of each cross product (i.e. each as nucleophile and electrophile, two reactions). and
Draw the reactant of the following reaction sequence.
Choose the best reagents to complete the reaction shown below.
4. Draw the aldehydes needed to prepare the compound below by an aldol reaction. OH CHO From: ogynu abmu and Vo
Alkyl diazonium salts decompose to form carbocations, which go on to form products of substitution, elimination, and (sometimes) rearrangement. Keeping this in mind, draw a stepwise mechanism that forms all of the following products.
Give Step by step solution
Draw a stepwise mechanism for the following variation of the aldol reaction, often called a nitro aldol reaction.
Provide the reagents necessary to affect each transformation
Step 3: If excess alcohol is present in the hemiacetal, the hemiacetal can be further converted to an acetal product, but only in the presence of acid. R₁ R₂ R3OH, H+ HO OR3 R3OH, H+ R3Q OR 3 + H2O R₁ R₁ R₂ hemiacetal acetal Why is acid required? The alkoxy group in the hemiacetal must first be converted into a good leaving group. Acid stabilizes the product. Acid stabilizes the hemiacetal, making it more reactive. The hydroxy group in the hemiacetal must first be converted into a good leaving group.

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