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1- 1,3-Bisphosphoglycerate (1,3-BPG) is a phosphoryl group donor during the synthesis of ATP in the reaction: 1,3-BPG + ADP → 3-Phosphoglycerate + ATP In human erythrocytes, the steady-state concentration of ATP is 2.24 mM, that of ADP is 0.25 mM, and that of 3-Phosphoglycerate is 0.15 mM. Calculate the concentration of 1,3-BPG at 25 °C, assuming that the above reaction is at the Equilibrium in the cell, and that the AGº of the reaction is -18.9 kJ/mol. Use D-8 315 /mol K and show vour work

1- 1,3-Bisphosphoglycerate (1,3-BPG) is a phosphoryl group donor during the synthesis of ATP in the reaction: 1,3-BPG + ADP → 3-Phosphoglycerate + ATP In human erythrocytes, the steady-state concentration of ATP is 2.24 mM, that of ADP is 0.25 mM, and that of 3-Phosphoglycerate is 0.15 mM. Calculate the concentration of 1,3-BPG at 25 °C, assuming that the above reaction is at the Equilibrium in the cell, and that the AGº of the reaction is -18.9 kJ/mol. Use D-8 315 /mol K and show vour work

Biochemistry
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
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1- 1,3-Bisphosphoglycerate (1,3-BPG) is a phosphoryl group donor during the synthesis of ATP in the reaction: 1,3-BPG + ADP → 3-Phosphoglycerate + ATP In human erythrocytes, the steady-state concentration of ATP is 2.24 mM, that of ADP is 0.25 mM, and that of 3-Phosphoglycerate is 0.15 mM. Calculate the concentration of 1,3-BPG at 25 °C, assuming that the above reaction is at the Equilibrium in the cell, and that the AG° of the reaction is -18.9 kJ/mol. Use R=8.315 J/mol.K and show your work. 2- In fact, the above reaction is maintained in a non-Equilibrium steady state in human erythrocytes; and the AG’ of the reaction is equal to -3.7 kJ/mol in these conditions. Calculate the concentration of 1,3-BPG at 25 °C in this non- Equilibrium steady state. Show your work.
Transcribed Image Text:1- 1,3-Bisphosphoglycerate (1,3-BPG) is a phosphoryl group donor during the synthesis of ATP in the reaction: 1,3-BPG + ADP → 3-Phosphoglycerate + ATP In human erythrocytes, the steady-state concentration of ATP is 2.24 mM, that of ADP is 0.25 mM, and that of 3-Phosphoglycerate is 0.15 mM. Calculate the concentration of 1,3-BPG at 25 °C, assuming that the above reaction is at the Equilibrium in the cell, and that the AG° of the reaction is -18.9 kJ/mol. Use R=8.315 J/mol.K and show your work. 2- In fact, the above reaction is maintained in a non-Equilibrium steady state in human erythrocytes; and the AG’ of the reaction is equal to -3.7 kJ/mol in these conditions. Calculate the concentration of 1,3-BPG at 25 °C in this non- Equilibrium steady state. Show your work.
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Step 1

Phosphoglycerate kinase is an enzyme catalyzing  the transfer of a phosphate group from 1,3-bisphosphoglycerate (1,3-BPG) in the following reaction:

1,3-bisphosphoglycerate + ADP ⇌ glycerate 3-phosphate + ATP

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