16. Fatty acid synthesis is carried out by fatty acid synthase, a single polypeptide that has multiple activities.The steps for fatty acid synthesis are given below. Number them in the order in which they occur._The ketobutyryl group is dehydrated.The acetyl group from the acetyl CoA istransferred to the malonyl group on the acylcarrier protein to form a ketobutyryl acyl carrierprotein.The acetyl group from the acetyl CoA isreduced by NADPH._The butenoyl is reduced.The butyrl group is transferred to the sitewhere the initial acetyl group from acetyl-CoAAn acetyl group from acetyl-CoA istransferred to the acyl carrier protein.once was.The acyl carrier protein transfers anacetyl group to another site on the fattyacid synthase.Malonyl-CoA is decarboxylated.The acyl carrier protein reacts with malonyl-CoA to pick up its malonyl group.

Fatty acid synthesis occurs by acetyl CoA and NADH in the cytosol by the series of enzymes known as…

Answered: .Fatty acid synthesis is carried out by…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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Help filling in the blanks: Pyridoxal phosphate, PLP, is produced from pyridoxine or vitamin B6. PLP is considered a/an [1C/2C/acyl/amino/carboxyl] carrier. In transaminases, PLP forms a [Schiff base/acetal/phosphoanhydride/condensation] with an amino acid and causes the [a- amino/a-carbon/a-carboxyl] to become [electrophilic/nucleophilic] allowing replacement of the amino group on the amino acid with a ketone. PLP is also used by several other enzymes that work on amino acids because in forming a covalent bond with amino acids it provides for an opportunity for nucleophilic attack and because PLP is conjugated, the cofactor is able to [delocalize/transfer/reduce/stabilize] pi electrons in the substrate and thus [stabilize/delocalize/transfer/reduce] the transition state of the reaction. Production of citrulline occurs in the [cytosol/mitochondrial matrix] while the rest of the urea cycle occurs in the [cytosol/mitochondrial matrix]. Urea is produced in the…
3. (a) Wakil's pioneering studies on fatty acid synthesis included the crucial observation that bicarbonate is required for the synthesis of palmitoyl-CoA. He was surprised to find that very low levels of bicarbonate could sustain palmitate synthesis; that is, there was no correlation between the amount of bicarbonate required and the amount of palmitate produced. Later he also observed that 14C-labeled bicarbonate is not incorporated into palmitate. Explain these observation (b) The condensation reaction catalyzed by B-ketoacyl-ACP synthase generates a 4-carbon unit by combining a 2-carbon unit with a 3-carbon unit and loss of CO2. Write with structural formulas how this occurs. What is the thermodynamic advantage of this way of generating the 4-carbon unit over combining two 2-carbon units as occurs fatty acid oxidation or ketone body reactions" (c) Decide where labeled carbon atoms will be found in palmitate if (i) (3-1“C)malonyl-SCOA or (ii) (2- 14C)malonyl-SCOA are used.
Before a fatty acid can undergo B-oxidation it must be: O Transport of the FA into the mito. matrix O Hydrolysis of the carboxyl group from the FA O Carboxylation of Acetyl-CoA to form malonyl-CoA Activation of the FA with Coenzyme A O Oxidation of the FA yielding a A2-enoyl intermediate
Describe the four types of reactions needed for fatty acid synthesis pathway that adds acetyl (C2) groups to a growing hydrocarbon chain. Include the names of the enzymes that catalyze each reaction.
I don't understand it. Can you help me? Can u help me to explain this to me, please?
In the first cycle of fatty acid synthesis via the acyl carrier protein system, the acetyl group on fatty acid synthase condenses with the malonyl-ACP complex. Draw the structure of the products of this reaction. Respresent ACP by R1 do not include free synthase Be sure to include charges on atoms at Ph=7
. Name the three unique reactions in gluconeogenesis.
OH The usage of acetyl-CoA in the cell depends on the metabolic / physiological state of the body. The table below shows the possible uses of acetyl-CoA, the corresponding physiological states of the body and the organ/cellular location where these processes occur. Identify which option is correct. Option Use of acetyl-CoA 1 2 3 4 Ketogenesis Cholesterol synthesis OOOO Fatty acid synthesis Oxidation via the citric acid cycle Select one: a. Option 1 b. Option 2 c. Option 3 O d. Option 4 Metabolic / Physiological state of the body Fasting state Fasting state Well fed Well fed Organ and cellular site Most cells / mitochondria Liver / cytoplasm Adipocyte / mitochondria Red blood cell / mitochondria Report question issue No
Select the BEST answer. Increasing the concentration of Fructose-2,6 bisphosphate would Inhibit Phosphofructokinase 2 Increase the concentration of Fructose-1,6 bisphosphate (phosphofructose isomerase) O increase the synthesis of glycogen Increase the carboxylation of Ac-CoA to make more malonyl-CoA increase the concentration of Pyruvate
Give Detailed Solution with explanation...(no need Handwritten)
Which of the following statements is true O Sphingomyelin posses phosphoryl serine in addition to two long hydrocarbon chains, one contributed by a fatty acid and the other by sphingosine OLipid compositions of membrane mono-layers are symmetrical O Unsaturated fatty acids have double bond(s) in the cis configuration In ABO blood typing, lack of glycosyltransferase and galactosyltransferase produces AB blood group
Protein: hexokinase, Role: The enzyme that carries out the first step of glycolysis (the first cytoplasmic phase of cellular respiration). Where is this protein synthesized? Be as specific as possible and briefly explain your choice

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