16. Fatty acid synthesis is carried out by fatty acid synthase, a single polypeptide that has multiple activities.The steps for fatty acid synthesis are given below. Number them in the order in which they occur._The ketobutyryl group is dehydrated.The acetyl group from the acetyl CoA istransferred to the malonyl group on the acylcarrier protein to form a ketobutyryl acyl carrierprotein.The acetyl group from the acetyl CoA isreduced by NADPH._The butenoyl is reduced.The butyrl group is transferred to the sitewhere the initial acetyl group from acetyl-CoAAn acetyl group from acetyl-CoA istransferred to the acyl carrier protein.once was.The acyl carrier protein transfers anacetyl group to another site on the fattyacid synthase.Malonyl-CoA is decarboxylated.The acyl carrier protein reacts with malonyl-CoA to pick up its malonyl group.

Fatty acid synthesis occurs by acetyl CoA and NADH in the cytosol by the series of enzymes known as…

Answered: .Fatty acid synthesis is carried out by…

Biochemistry

6th Edition

ISBN:9781305577206

Author:Reginald H. Garrett, Charles M. Grisham

Publisher:Reginald H. Garrett, Charles M. Grisham

Chapter18: Glycolysis

Section: Chapter Questions

Problem 14P: Energetic of Fructose-1 ,6-bis P Hydrolysis (Integrates with Chapter 3.) The standard free energy...

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1. Explain the reaction mechanism involved how glucogenic amino acids can yield either a pyruvic acid or an oxaloacetic acid. In what pathway will pyruvic or oxaloacetic acid be used and why is this pathway important? 2. Discuss the reaction mechanism involved how the -NH2 groups of amino acids are being metabolized. 3. Explain why gluconeogenesis under conditions of starvation or diabetes breaks down body proteins. Complete answer please. Thank you. |
Which of the following is NOT part of the multi-enzyme complex of fatty acid synthase? O enoyl-ACP reductase O acetyl CoA carboxylase O 3-hydroxybutyrylACP-dehydratese O B-ketoacyl-ACP reductase
NH, This compound is directly involved in: он O=P-0-CH, H но OmP-0- O oxidizing an alcohol in the conversion of sucrose to fructose. O the synthesis of malonyl coenzyme A. reducing a ketone in gluconeogenesis. reducing a C=C double bond in fatty-acid synthesis.
A diagram of the reactions of the first round of fatty acid synthesis (lipogenesis) is shown. How many cycles of the synthesis pathway are needed to produce lauric acid, C11H23COOH? || CH3 C S KSO-C-CH₂-C-SACP acetyl-ACP malonyl-ACP CO₂ || CH3 C-CH₂-C-SACP || NADPH + H+ NADP+ OH 요 CH3 CH-CH₂-C-SACP d ord H₂O CH3CH=CH-C-SACP d NADPH + H+ NADP+ CH3CH₂CH2 C-SACP number of cycles:
Help filling in the blanks: Pyridoxal phosphate, PLP, is produced from pyridoxine or vitamin B6. PLP is considered a/an [1C/2C/acyl/amino/carboxyl] carrier. In transaminases, PLP forms a [Schiff base/acetal/phosphoanhydride/condensation] with an amino acid and causes the [a- amino/a-carbon/a-carboxyl] to become [electrophilic/nucleophilic] allowing replacement of the amino group on the amino acid with a ketone. PLP is also used by several other enzymes that work on amino acids because in forming a covalent bond with amino acids it provides for an opportunity for nucleophilic attack and because PLP is conjugated, the cofactor is able to [delocalize/transfer/reduce/stabilize] pi electrons in the substrate and thus [stabilize/delocalize/transfer/reduce] the transition state of the reaction. Production of citrulline occurs in the [cytosol/mitochondrial matrix] while the rest of the urea cycle occurs in the [cytosol/mitochondrial matrix]. Urea is produced in the…
3. (a) Wakil's pioneering studies on fatty acid synthesis included the crucial observation that bicarbonate is required for the synthesis of palmitoyl-CoA. He was surprised to find that very low levels of bicarbonate could sustain palmitate synthesis; that is, there was no correlation between the amount of bicarbonate required and the amount of palmitate produced. Later he also observed that 14C-labeled bicarbonate is not incorporated into palmitate. Explain these observation (b) The condensation reaction catalyzed by B-ketoacyl-ACP synthase generates a 4-carbon unit by combining a 2-carbon unit with a 3-carbon unit and loss of CO2. Write with structural formulas how this occurs. What is the thermodynamic advantage of this way of generating the 4-carbon unit over combining two 2-carbon units as occurs fatty acid oxidation or ketone body reactions" (c) Decide where labeled carbon atoms will be found in palmitate if (i) (3-1“C)malonyl-SCOA or (ii) (2- 14C)malonyl-SCOA are used.
All of the following are accurate contrasts for beta oxidation vs fatty acid synthesis except which of the following statements? Group of answer choices The hydroxylacyl group differs in stereochemistry between beta oxidation and biosynthesis CoA is the acyl carrier group in beta oxidation, acyl carrier protein is the carrier in biosynthesis The carbon unit resulting from beta oxidation is acetyl-CoA, the carbon unit for biosynthesis is malonyl-CoA FAD is an electron acceptor in beta oxidation, NADP+ is the electron acceptor in biosynthesis
6. The five steps involved in conversion of pyruvate to acetyl-CoA are listed below. For each step, list the enzyme(s) that are involved. 1. Decarboxylate pyruvate 2. Reduction of lipoic acid 3. Transfer of acetyl group to coenzyme A 4. Reoxidation of lipoic acid 5. Reoxidation of FADH2 → FAD
What is(are) the only active site(s) not used in the second round of fatty acid synthase? Select all that apply. Acetyl-CoA ACP Transacylase Beta-Ketoacyl- ACP Synthase Beta-Ketoacyl- ACP Dehydrase Palmitoyl thioesterase Malonyl-CoA ACP Transacylase Enoyl-ACP Reductase
Only one acetyl CoA molecule is used directly in fatty acid synthesis. Identify the carbon atoms in palmitic acid that were donated by acetyl CoA.
1. Discuss fully the synthesis of triacylglycerol in the adipose tissue, muscles, intestines and liver. 2. Describe adequately the beta-oxidation of fatty acids. 3. Discuss the synthesis and utilization of ketone bodies.
Select the incorrect match 1.Acetyl CoA — Gibberellins 2.Succinyl CoA — Terpenes 3.Oxalo acetic acid — Pyrimidines 4.a-ketoglutaric acid —Amino acid synthesis

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