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COLLEGE OF ENGINEERING, UIC BME 520, Elastography, credit hours: 4 I. Instructor & Course Details Instructor: Dieter Klatt, Ph.D. Email address: dklatt@uic.edu Drop-In Office Hours: in-person by appointment. Drop-In Hours location: West Campus, BME Area, Rm 110B. TA: Jimit Kapadia Email address: jkapad4@uic.edu Drop-In Office Hours: in-person Thursdays 12:30 – 2:30 pm. Drop-In Hours location: SEO, Rm 219 B. Blackboard Course Site https://uic.blackboard.com/ultra/courses/_259203_1/cl/outline Students are expected to log into the course site regularly to learn about any developments related to the course, upload assignments, and communicate with classmates. For all technical questions about Blackboard, email the Learning Technology Solutions team at LTS@uic.edu. Course Modality and Schedule This course is taught ON CAMPUS . - Tuesdays and Thursdays, 3:30 - 4:45 pm. - East Campus, LH 312. II. Course Information Catalog Course Description and Prerequisite/Corequisite Statement Theoretical foundations of elastography, viscoelasticity, propagation of mechanical waves, elastographic imaging techniques. Magnetic resonance imaging to magnetic resonance elastography data transformation, viscoelastic parameter reconstruction. Course Information: same as ME 520. Extensive computer use required. Recommended background: BME 421 and BME 422 and BME 423. Graduate standing required or consent of instructor. Course materials and assignments can be complex and challenging, but they are crucial to your intellectual and personal growth and development. There are times you may need extra help. Students who attend class consistently, complete all assignments, thoughtfully engage with feedback on work, develop good study strategies, visit the tutoring center, and contact faculty when they are struggling can develop a thorough understanding of the course material and ultimately succeed in the course!

2 Course Goals and Learning Outcomes Accreditation Board for Engineering and Technology (ABET) outcomes addressed by this course. At the end of the semester, students will have: 1. an ability to identify, formulate, and solve complex engineering problems by applying principles of engineering, science, and mathematics. 2. an ability to apply engineering design to produce solutions that meet specified needs with consideration of public health, safety, and welfare, as well as global, cultural, social, environmental, and economic factors. 3. an ability to communicate effectively with a range of audiences. 4. an ability to develop and conduct appropriate experimentation, analyze and interpret data, and use engineering judgment to draw conclusions. 5. an ability to acquire and apply new knowledge as needed, using appropriate learning strategies. Course learning objectives . At the end of the semester students will have: - the understanding of how pathological changes impact the mechanical properties of biological tissue. - knowledge about the diagnostic potential of elastographic techniques. - the ability to process imaging raw data towards images of mechanical tissue properties. - knowledge of the theoretical foundations of continuum mechanics and rheology. - knowledge about the pros and cons of diverse elastographic techniques. Brief list of topics to be covered: - interaction between pathology and mechanical tissue properties. - continuum mechanics. - rheology. - viscoelastic wave propagation. - ultrasound elastography. - magnetic resonance elastography. Required and Recommended Course Materials No required textbooks. Useful references recommended for further reading: Hirsch S, Braun J, Sack I, Magnetic Resonance Elastography: Physical Background and Medical Applications (2017); ISBN-10:3527340084; Wiley, NY. KJ Glaser, A Manduca, RL Ehman, Review of MR Elastography Applications and Recent Developments, Journal of Magnetic Resonance Imaging (2012) 36, 757-774. Muller, Gerhard. Theory of Elastic Waves. Lecture notes (can be found on Blackboard). Class notes will be available as pdfs on the Blackboard course site.

3 Required Technology Internet access is needed to access course materials online (Blackboard site) and to take the online quizzes. MATLAB or any other numeric computing platform is required for some homework assignments and for the final project. Students should contact the instructor in cases of difficulty with accessing the course materials online. There is a free MATLAB student version available via Webstore that the students can use on their own device or via the UIC’s Virtual Computer Lab. Students may purchase Adobe Creative Cloud applications via Webstore and then access them using their license on their own device or via the UIC’s Virtual Computer Lab. Students in financial hardship may request access to Adobe Creative Cloud when following the Webstore process for licensing requests. Remote access will require UIC’s Virtual Private Network (VPN) services. Respect for Copyright Please protect the copyright integrity of all course materials and content. Please do not upload course materials not created by you onto third-party websites or share content with anyone not enrolled in our course. III. COURSE POLICIES & CLASSROOM EXPECTATIONS Grading Policy and Point Breakdown There are 14 weekly quizzes with questions in multiple answer style , where either none, one or multiple answers are correct. Quizzes are posted on the Blackboard Thursday after class and are due the next Tuesday at 3:00 pm. Students score one point for each question answered correctly. There are five homework assignments. The due date is one week after the homework has been assigned (see IV. COURSE SCHEDULE). Students can score 30 points in each of the five assignments. A final project will be assigned in week 13 and is due on Friday, December 1 st 2023, end of day. Students can score 90 points in the final project. Weighing of assessment types Homework (5 assignments) (50%) Weekly Quizzes. (20%) Final Project (30%)

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4 Letter grade Grade Weighted overall percentage A ≥ 90% B ≥ 80% C ≥ 70% D ≥ 60% F < 60% Policy for Missed or Late Work Quizzes are administered via Blackboard and, after assignment, the solutions are due the next Tuesday at 3:00 pm. Missed or late quizzes will be graded with 0 points. Students are allowed one late homework assignment within 72 hours of due date/time without penalty during the semester. Otherwise, a penalty of 10 points per day will be imposed on late homework assignments. A penalty of 10 points per day will be imposed on late final projects. Attendance / Participation Policy Attendance and participation in class are strongly encouraged but are not required. Please email me if you face an unexpected situation that may impede your attendance, participation in class, or timely completion of assignments. Academic Integrity As a student and member of the UIC community, you are expected to adhere to the Community Standards of academic integrity , accountability, and respect. Please review the UIC Student Disciplinary Policy for additional information. Email Expectations Students are responsible for all information instructors send to your UIC email and Blackboard accounts. Faculty messages should be regularly monitored and read in a timely fashion. IV. COURSE SCHEDULE Week 1 : Introduction: why elastography. Week 2 : Introduction: what is stiffness? Strain theory; HW 1 assignment. Week 3 : Hooke’s law; elastic wave equation; HW 1 due. Week 4 : Theory of linear viscoelasticity; HW 2 assignment. Week 5 : Correspondence principle; viscoelastic wave equation; HW 2 due.

5 Week 6 : Quasi-static methods; scanning laser doppler vibrometry; introduction to conventional ultrasound; HW 3 assignment. Week 7 : Ultrasound elastography; optical coherence elastography; HW 3 due. Week 8 : Principles of conventional MR imaging: introduction and MR physics. Week 9 : Conventional MR imaging: hardware and image acquisition; HW 4 assignment Week 10 : Conventional MR imaging: contrast parameters; motion-encoding MR imaging; HW 4 due Week 11 : MR elastography: hardware and motion-encoding strategies. Week 12 : Data processing and mechanical parameter reconstruction MR elastography; HW 5 assignment. Week 13 : New developments in MR elastography; HW 5 due; final project assignment. Week 14 : Final project practice. Week 15 : Tour to RSNA; final project practice; final project due. Disclaimer This syllabus is intended to give the student guidance on what may be covered during the semester and will be followed as closely as possible. However, as the instructor, I reserve the right to modify, supplement, and make changes as course needs arise. I will communicate such changes in advance through in-class announcements and in writing via Blackboard Announcements. V. ACCOMMODATIONS Disability Accommodation Procedures UIC is committed to full inclusion and participation of people with disabilities in all aspects of university life. If you face or anticipate disability-related barriers while at UIC, please connect with the Disability Resource Center (DRC) at drc.uic.edu, via email at drc@uic.edu, or call (312) 413-2183 to create a plan for reasonable accommodations. To receive accommodations, you will need to disclose the disability to the DRC, complete an interactive registration process with the DRC, and provide me with a Letter of Accommodation (LOA). Upon receipt of an LOA, I will gladly work with you and the DRC to implement approved accommodations. Religious Accommodations Following campus policy , if you wish to observe religious holidays, you must notify me by the tenth day of the semester. If the religious holiday is observed on or before the tenth day of the semester, you must notify me at least five days before you will be absent. Please submit this form by email with the subject heading: “YOUR NAME: Requesting Religious Accommodation.”

6 VI. CLASSROOM ENVIRONMENT Inclusive Community UIC values diversity and inclusion. Regardless of age, disability, ethnicity, race, gender, gender identity, sexual orientation, socioeconomic status, geographic background, religion, political ideology, language, or culture, we expect all members of this class to contribute to a respectful, welcoming, and inclusive environment for every other member of our class. If aspects of this course result in barriers to your inclusion, engagement, accurate assessment, or achievement, please notify me as soon as possible. Name and Pronoun Use If your name does not match the name on my class roster, please let me know as soon as possible. My pronouns are [he/him] . I welcome your pronouns if you would like to share them with me. For more information about pronouns, see this page: https://www.mypronouns.org/what-and-why . Community Agreement/Classroom Conduct Policy ● Be present by turning off cell phones and removing yourself from other distractions. ● Be respectful of the learning space and community. For example, no side conversations or unnecessary disruptions. ● Use preferred names and gender pronouns. ● Assume goodwill in all interactions, even in disagreement. ● Facilitate dialogue and value the free and safe exchange of ideas. ● Try not to make assumptions, have an open mind, seek to understand, and not judge. ● Approach discussion, challenges, and different perspectives as an opportunity to “think out loud,” learn something new, and understand the concepts or experiences that guide other people’s thinking. ● Debate the concepts, not the person. ● Be gracious and open to change when your ideas, arguments, or positions do not work or are proven wrong. ● Be willing to work together and share helpful study strategies. ● Be mindful of one another’s privacy, and do not invite outsiders into our classroom. Content Notices and Trigger Warnings Our classroom provides an open space for a critical and civil exchange of ideas, inclusive of a variety of perspectives and positions. Some readings and other content may expose you to ideas, subjects, or views that may challenge you, cause you discomfort, or recall past negative experiences or traumas. I intend to discuss all subjects with dignity and humanity, as well as with rigor and respect for scholarly inquiry. If you would like me to be aware of a specific topic of concern, please email me or schedule an appointment to see me in person.

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7 VII. RESOURCES: Academic Success, Wellness, and Safety We all need the help and the support of our UIC community. Please contact me via email for course consultation and other academic or research topics. For additional assistance, please contact your assigned college advisor and visit the support services available to all UIC students. Academic Success ● UIC Tutoring Resources ● College of Engineering tutoring program ● Equity and Inclusion in Engineering Program ● UIC Library and UIC Library Research Guides. ● Offices supporting the UIC Undergraduate Experience and Academic Programs. ● Student Guide for Information Technology Wellness ● Counseling Services : You may seek free and confidential services from the Counseling Center at https://counseling.uic.edu/. ● Access U&I Care Program for assistance with personal hardships. ● Campus Advocacy Network : Under Title IX, you have the right to an education that is free from any form of gender-based violence or discrimination. To make a report, email TitleIX@uic.edu. For more information or confidential victim services and advocacy, visit UIC’s Campus Advocacy Network at http://can.uic.edu/. Safety ● UIC Safe App —PLEASE DOWNLOAD FOR YOUR SAFETY! ● UIC Safety Tips and Resources ● Night Ride ● Emergency Communications : By dialing 5-5555 from a campus phone, you can summon the Police or Fire for any on-campus emergency. You may also set up the complete number, (312) 355-5555, on speed dial on your cell phone.