Senior Seminar (2)
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Fisher College *
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MISC
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Health Science
Date
Nov 24, 2024
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docx
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2
Uploaded by MasterMusic7412
Maisa Lopes
Dr. Kim
Senior Seminar
Assignment 2
09/22/2023
Exploring the Role of Random Genetic Drift in Pediatric Cancer Development Using the E.
coli Long-Term Evolution Experiment
"Exploring the Role of Random Genetic Drift in Pediatric Cancer Development," according to
the study. Using the E. coli Long-Term Evolution Experiment" aims to modify the E. coli long-
term evolution experiment, with a focus on the mutation accumulation (MA) experiment, to
investigate the potential role of random genetic drift in the genesis of cancer in pediatric patients.
This study aims to shed light on whether similar stochastic processes may contribute to pediatric
cancer initiation by subjecting E. coli populations to long-term selection-free conditions and
monitoring mutation accumulation over generations. This novel approach could provide
important insights into the genetic and evolutionary factors that contribute to pediatric cancer,
potentially opening up new avenues for prevention and treatment. Researchers may be able to
develop more targeted therapies and early detection methods by better understanding the role of
random genetic drift in cancer development, ultimately improving outcomes for young cancer
patients.
References:
Lenski, R. E., & Travisano, M. (1994). Dynamics of adaptation and diversification: A
10,000-generation experiment with bacterial populations. Proceedings of the National Academy
of Sciences of the United States of America, 91(15), 6808-6814.
Sniegowski, P. D., Gerrish, P. J., & Lenski, R. E. (1997). Evolution of high mutation rates
in experimental populations of E. coli. Nature, 387(6634), 703-705.
Cancer Survivorship and Quality of Life
"Cancer Survivorship and Quality of Life" delves into the intricate and multifaceted journey that
cancer survivors navigate, encompassing the physical, psychological, and social challenges they
face during and after cancer treatment. Understanding how these people deal with the aftereffects
of cancer is critical to improving their overall quality of life. It entails looking into things like
how to manage treatment-related side effects, how to deal with psychological distress, how to
deal with changes in social relationships, and how to deal with potential long-term health risks.
Researchers want to find effective interventions, support systems, and healthcare strategies that
will allow cancer survivors to not only survive but thrive in the face of adversity. The study also
considers the role of healthcare systems in providing comprehensive care and support,
emphasizing the importance of a smooth transition from active treatment to long-term
survivorship care. As cancer survivorship rates rise, understanding survivors' experiences and
needs becomes increasingly important for improving their well-being and ensuring they receive
the best possible care and support throughout their journey.
References:
Stanton, A. L., Ganz, P. A., Rowland, J. H., Meyerowitz, B. E., Krupnick, J. L., & Sears,
S. R. (2005). Promoting adjustment after treatment for cancer. Cancer, 104(11 Suppl), 2608-
2613.
Hewitt, M. E., Greenfield, S., & Stovall, E. (2006). From Cancer Patient to Cancer
Survivor: Lost in Transition. National Academies Press.
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