F23B1E3%5BPractice%5DFinal

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Biology

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Apr 3, 2024

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Bio1. Quiz 3 Last Name [Print]: First name [Print]: Student ID # [Print]: Indicate your recitation section [All Tuesday]: R1 @ 9 am R2@ 10 am R3@ 12 pm R4@ 1 pm Please note by submitting the Exam you are agreeing with the following academic statement : "I acknowledge that I am aware of the University of Pittsburgh’s student code of conduct, and the Dietrich School of Arts and Sciences policy concerning academic honesty, integrity, plagiarism, and cheating. I further attest that the work I am submitting with this exam is solely my own and was developed during the exam. I have accessed only my permitted materials during the exam. I have not recorded an image of this exam, nor have I had any contact with a fellow student during the exam. I further attest that I hold myself to the high academic standards expected of me." Violation of the academic integrity statement will result in a zero score being applied, which cannot be dropped from your final grade. Signature: Score Card You may detach the scorecard, but ONLY the scorecard as you work. All pages of this exam must be returned before you leave the classroom. Section 1: Fill in the blank section Please transfer your final answers to the corresponding box below. Your answer should be a scientific description or term (2 words max). Only answers in the scoring card will be accepted. If a response is not clearly legible, or you enter multiple answers, no points will be awarded for that question. [1 point each] Blank 1 Blank 2 Blank 3 Blank 4 Blank 5 Blank 6 Blank 7 Blank 8 Blank 9 Blank 10

Bio1. Quiz 3 Section 2: Open response. Enter response(s) as per question prompt. Only answers in the scoring card will be accepted. If a response is not clearly legible, or you enter multiple answers (unless otherwise directed), no points will be awarded for that question. [2 points each] Q.11 Letter sequence in correct order Start=> =>End Q.12 Responses Occurring: Not occurring: Q.13 Letter Q.14 Agonist: Antagonist: Q.15 Kinesin to: Dynein to: Q.16 Process Q.17 Cross-section Q.18 Arrow Q.19 A. B. C. Q.20 Number MI: Section 3: Multiple-Choice section. Enter the corresponding letter for your [one] answer choice. If you enter multiple responses per question, or if your letter choice isn’t clearly legible no points will be awarded for the question [2 points each] Q.21 Q.22 Q.23 Q.24 Q.25 Q.26 Q.27 Q.28 Q.29 Q.30 Q.31 Bonus

Bio1. Quiz 3 Last Name [Print]: First name [Print]: Student ID # [Print]: Indicate your recitation section [All Tuesday]: R1 @ 9 am R2@ 10 am R3@ 12 pm R4@ 1 pm Reference Tables DO NOT DETACH THE REFERENCE TABLES OR ANY OTHER PAGES FROM THE EXAM Section 1: Fill in the blank Select the correct scientific word(s), term, or description to complete the sentence (2 words max). Please transfer your final answers as [directed in the question prompt] to section 1 of the scorecard. Only answers on the scorecard will be accepted. Please write legibly; if your answer isn’t clearly legible no points will be awarded for the question. The fill in the blank questions are worth 1 point each. Q.1 The <Blank 1> system consists of the nucleus, endoplasmic reticulum, golgi, lysosome and cell membrane (term describing this collection of organelles). Q.2 A <Blank 2> coated vesicle moves vesicles from the Golgi to the cell membrane (type of vesicle coat). Q.3 <Blank 3> describes the interaction between multiple pathways involving secondary messengers, to have a coordinated cellular response (term describing this specific interaction). Q.4 <Blank 4> filaments anchor cell structures in place within the cell (specific cytoskeletal component). Q.5 Signal transduction ends with the cellular <Blank 5> component of a signaling pathway (one of the three sections of cell signaling). Q.6 An <Blank 6> receptor is a membrane receptor which allows for direct facilitated diffusion of ions upon ligand binding (type of receptor). Q.7 The intracellular non-protein components of a signaling pathway are collectively called <Blank 7> (Term for components seen more frequently with membrane receptors).

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Bio1. Quiz 3 Q.8 In a pathway where molecules are broken down and ATP is produced this is a <Blank 8> process (term encompassing all break-down reactions). Q.9 The <Blank 9> model for enzyme-substrate interaction describes a change in enzyme shape upon substrate binding in the active site (term describing the enzyme shape change). Q.10 Enzymes speed up biochemical reactions by lowering the <Blank 10 > of the reaction (term describing the energy change). Transfer your final answer to Section 1 of the ScoreCard on Page 1 => Section 2: Open Response. Please transfer your final answer to the scorecard. Only answers on the scorecard will be accepted. You may detach this scorecard as you work but must return both the scorecard and exam before leaving the classroom. For this section, please enter your response as directed in the question prompt. If you enter multiple responses (other than directed) per question, or if your response isn’t clearly legible, no points will be awarded for the question. Q.11 Build your pathway. Put the components in the box in the correct order in which they function in a signal transduction pathway. In this pathway the receptor is a G-protein coupled receptor, and the second messenger activates the kinase cascade. Phosphorylation of the transcription factor is the cellular response. Note: All components will be used one time in this signal transduction. A. Transcription factor phosphorylation B. Primary Message binding C. cAMP levels increase D. Kinase cascade activation E. Receptor activation F. Adenylate Cyclase (AC) activation G. G protein activation Start => => => => => => => => End Transfer your final answer to Section 2 of the ScoreCard on Page 2 =>

Bio1. Quiz 3 Q.12 Crosstalk allows cells to integrate multiple signals for a coordinated cellular response. Below is a graphical representation of four signaling pathways. The circles represent a kinase cascade (K1-4) in the signal transduction of the pathway, and the response is noted in the box at the bottom of each pathway. The inhibitory (attenuated) and stimulatory crosstalk via second messengers is indicated. Which cellular responses would occur if ligand was bound at receptor A, B and D (C is unstimulated, with no ligand bound). Responses occurring: Responses not occurring: Transfer your final answer to Section 2 of the ScoreCard on Page 2 => Q.13 The hydrolysis of ATP is as follows: ATP → ADP +Pi ΔG o = -7.3 kcal/mol. Which reaction would the hydrolysis of one ATP molecule most likely be coupled to? Reaction: Transfer your final answer to Section 2 of the ScoreCard on

Bio1. Quiz 3 Page 2 => Q.14 Which Ligand would be the best agonist and antagonist drug when compared to the natural ligand. Agonist: Antagonist: Transfer your final answer to Section 2 of the ScoreCard on Page 2 => Q.15 Vesicles are coated specific membrane proteins, so each vesicle can be sorted to its correct cellular location. Which motor protein would move vesicles from Organelle B to organelle A. Kinesin will transport vesicles to organelle Dynein will transport vesicles to organelle Transfer your final answer to Section 2 of the ScoreCard on Page 2 => Q.16 Observe the cellular process illustrated below. The cell membrane invaginates inwards in response to the solutes (balls) binding to a membrane receptor. Name this process in the box below. Process: Transfer your final answer to Section 2 of the ScoreCard on Page 2 =>

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Bio1. Quiz 3 Q.17 Refer to the schematic of a structural element within the cell. Which cross-section (A,B or C) would correspond to a cilia in a eukaryotic cell. Enter the corresponding letter in the box below. Cross-section: Transfer your final answer to Section 2 of the ScoreCard on Page 2 => Q.18 The image below shows the reaction of I + J → K + L. Which arrow corresponds to the ΔG of the enzyme-catalyzed reaction? Enter the corresponding letter in the box below. Arrow: Transfer your final answer to Section 2 of the ScoreCard on Page 2 => *L24 Content* Q.19 Complete the table describing the relationship between the inhibition types and their Michaelis constant (K m ) and Maximal Velocity (V max ) values K m value V max Value Competitive Altered C. Uncompetitive B. Altered A. Unaltered Altered Transfer your final answer to Section 2 of the ScoreCard on Page 2 =>

Bio1. Quiz 3 *L24 Content* Q.20 Refer to the schematic illustration a biosynthetic pathway, with the metabolic intermediates (MI) 1-4 labeled. Which intermediate is the effector in feedback inhibition. Enter the Intermediate name in the box. MI: Transfer your final answer to Section 2 of the ScoreCard on Page 2 => Section 3: Multiple Choice. Please transfer your final answer to the scorecard. Only answers on the scorecard will be accepted. You may detach this scorecard as you work but must return both the scorecard and exam before leaving the classroom. For this section, please enter one response per question. If you enter multiple responses per question, or if your letter choice isn’t clearly legible, no points will be awarded for the question. Q.21 If a protein has an ER signal peptide and no other signal peptides within the polypeptide sequence is destined

Bio1. Quiz 3 a. for post-translational trafficking and remains in the cytoplasm. b. for co-translational trafficking and remains in the cytoplasm. c. for post-translational trafficking and secretion. d. for co-translational trafficking and secretion. e. for post-translational trafficking but remains in the rough endoplasmic reticulum. f. for co-translational trafficking but remains in the rough endoplasmic reticulum. g. for post-translational trafficking to the nucleus. h. for co-translational trafficking to the nucleus. Transfer your final answer to Section 3 of the ScoreCard on Page 2 => Q.22 Select the correct statement regarding cilia “swimming” movement. a. Dynein walks along the microtubules facilitating the cilia bending. b. Dynein crosslinks the microfilaments facilitating the cilia bending. c. Dynein and actin binding proteins crosslink the microtubule facilitating the cilia bending. d. Dynein and nexin crosslink the microtubules facilitating the cilia bending. Transfer your final answer to Section 3 of the ScoreCard on Page 2 => Q.23 Select the incorrect statement describing lysosomal digestion of a large food particle in an amoeba. a. The primary lysosome buds off from the golgi. b. The food particle is brought into the cell by phagocytosis. c. The secondary lysosome is formed by fusion of the primary lysosome with the phagosome. d. Recyclable materials are released into the cytosol. e. Undigested materials are released from the cell via endocytosis. Transfer your final answer to Section 3 of the ScoreCard on Page 2 =>

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Bio1. Quiz 3 Q.24 Select the correct statement that applies to the ligand-receptor interaction. a. Membrane receptors can become a transcription factor when the ligand binds. b. The ligand is converted to product and released from the receptor. c. Signal transduction occurs regardless of ligand binding to the receptor. d. Binding to the receptor induces a conformational change to the ligand. e. Ligands for intracellular receptors are small and non-polar. Transfer your final answer to Section 3 of the ScoreCard on Page 2 => Q.25 Free energy is a. enthalpy. b. entropy. c. usable energy. d. unusable energy. e. total energy. Transfer your final answer to Section 3 of the ScoreCard on Page 2 => Q.26 Refer to the tables below. You observe the following about a biochemical reaction: Reactants Products Number and type of molecules 5 large molecules 40 small molecules Number and types of bonds 5 non-polar covalent double bonds 35 non-polar covalent bonds 5 polar covalent double bonds 10 non-polar covalent bonds 25 polar covalent bonds

Bio1. Quiz 3 (f )= favorable; (uf) = unfavorable a. the reaction is spontaneous at all temperatures. b. the reaction is non-spontaneous at all temperatures. c. the reaction is spontaneous at high temperatures. d. the reaction is spontaneous at low temperatures. Transfer your final answer to Section 3 of the ScoreCard on Page 2 => Q.27 Which statement regarding enzymes is false a. Enzymes orient the substrates in the active site to they can interact. b. Enzymes induce strain to the chemical bonds of the substrate. c. Enzymes use acid-base catalysis to induce product instability. d. Enzymes lower the activation energy of the reaction. e. Substrate binding induces a conformational change to the Enzyme. Transfer your final answer to Section 3 of the ScoreCard on Page 2 => Q.28 Cardiomyocytes are the cells responsible for the contractile force of the heart. They synthesize and release a signal ligand into the circulatory system. The signal ligand binds to receptors only present on neurons as a positive feedback mechanism, letting the brain know the heartbeat is regular. This is known as a. autocrine signaling. b. juxtacrine signaling. c. paracrine signaling. d. endocrine signaling. Transfer your final answer to Section 3 of the ScoreCard on Page 2 =>

Bio1. Quiz 3 Q.29 What part of the enzyme does the substrate bind to for catalysis to occur? a. active site b. initiation site c. transformation site d. allosteric site Transfer your final answer to Section 3 of the ScoreCard on Page 2 => Q.30 Refer to the image illustrating the energy changes associated with an enzyme catalyzed reaction. Select the correct statement corresponding to Arrow A a. Arrow A represents the substrate binding. b. Arrow A represents the transition state of the reaction. c. Arrow A represents the confirmational change to the enzyme. d. Arrow A represents the final product form. Transfer your final answer to Section 3 of the ScoreCard on Page 2 => Q.31 bonus The standard free energy change for the hydrolysis of GTP (guanosine triphosphate) to GDP + Pi is –7.3 kcal/mol, similar to that for ATP. From this information, one can conclude that the a. reaction will never reach equilibrium. b. free energy of GDP and Pi is higher than the free energy of GTP. c. the reaction does not require an activation energy (E a ). d. reaction is endergonic and spontaneous. e. reaction is exergonic and spontaneous.

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Bio1. Quiz 3 Transfer your final answer to Section 3 of the ScoreCard on Page 2 => Finished? Please check you transferred all your final answers to the ScoreCard and return both the ScoreCard and Exam to your TA before leaving.

F23B1E3%5BPractice%5DFinal

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