Biol2000 Problem set Chp 2-3

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Q 54. In the pedigree below, the black symbols represent individuals with a very rare blood disease. If you had no other information to go on, would you think it more likely that the disease was dominant or recessive? Give your reasons. Q 55. a. The ability to taste the chemical phenylthiocarbamide is an autosomal dominant phenotype, and the inability to taste it is recessive. If a taster woman with a nontaster father marries a taster man who had a nontaster daughter in a previous marriage, what is the probability that their first child will be: 1. a nontaster girl? 2. a taster girl? 3. a taster boy? b. What is the probability that their first two children will be tasters of either sex? Q 56. John and Martha are contemplating having children, but John’s brother has galactosemia (an autosomal recessive disease) and Martha’s great-grandmother also had galactosemia. Martha has a sister who has three children, none of whom have galactosemia. What is the probability that John and Martha’s first child will have galactosemia? Q63. Four human pedigrees are shown in the accompanying illustration. The black symbols represent an abnormal phenotype inherited in a simple Mendelian manner. a. For each pedigree, state whether the abnormal condition is dominant or recessive. Try to state the logic behind your answer. b. For each pedigree, describe the genotypes of as many persons as possible.
Q65. The following pedigree was obtained for a rare kidney disease. a. Deduce the inheritance of this condition, stating your reasons. b. If persons 1 and 2 marry, what is the probability that their first child will have the kidney disease? Q69. A rare recessive allele inherited in a Mendelian manner causes the disease cystic fibrosis. A phenotypically normal man whose father had cystic fibrosis marries a phenotypically normal woman from outside the family, and the couple consider having a child. a. Draw the pedigree as far as described. b. If the frequency in the population of heterozygotes for cystic fibrosis is 1 in 50, what is the chance that the couple’s first child will have cystic fibrosis? c. If the first child does have cystic fibrosis, what is the probability that the second child will be normal? Q71. The recessive allele s causes Drosophila to have small wings and the s+ allele causes normal wings. This gene is known to be X-linked. If a small-winged male is crossed with a homozygous wild-type female, what ratio of normal to small-winged flies can be expected in each sex in the F1? If F1 flies are intercrossed, what F2 progeny ratios are expected? What progeny ratios are predicted if F1 females are backcrossed with their father? Q73. Duchenne muscular dystrophy is sex-linked and usually affects only males. Victims of the disease become progressively weaker, starting early in life. a. What is the probability that a woman whose brother has Duchenne’s disease will have an affected child? b. If your mother’s brother (your uncle) had Duchenne’s disease, what is the probability that you have received the allele?
c. If your father’s brother had the disease, what is the probability that you have received the allele? Q77. A sex-linked recessive allele c produces a red–green color blindness in humans. A normal woman whose father was color-blind marries a color-blind man. a. What genotypes are possible for the mother of the color-blind man? b. If the couple has children, what are the chances that the first child from this marriage will be a color- blind boy? c. Of the girls produced by these parents, what proportion can be expected to be colorblind? d. Of all the children (sex unspecified) of these parents, what proportion can be expected to have normal color vision?
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